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Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Her...

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Autores principales: Cardoso, Beatriz D., Rodrigues, Ana Rita O., Almeida, Bernardo G., Amorim, Carlos O., Amaral, Vítor S., Castanheira, Elisabete M. S., Coutinho, Paulo J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279386/
https://www.ncbi.nlm.nih.gov/pubmed/32455630
http://dx.doi.org/10.3390/ijms21103641
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author Cardoso, Beatriz D.
Rodrigues, Ana Rita O.
Almeida, Bernardo G.
Amorim, Carlos O.
Amaral, Vítor S.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
author_facet Cardoso, Beatriz D.
Rodrigues, Ana Rita O.
Almeida, Bernardo G.
Amorim, Carlos O.
Amaral, Vítor S.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
author_sort Cardoso, Beatriz D.
collection PubMed
description Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, Ca(x)Mg(1−x)Fe(2)O(4) (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.
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spelling pubmed-72793862020-06-17 Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release Cardoso, Beatriz D. Rodrigues, Ana Rita O. Almeida, Bernardo G. Amorim, Carlos O. Amaral, Vítor S. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. Int J Mol Sci Article Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, Ca(x)Mg(1−x)Fe(2)O(4) (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release. MDPI 2020-05-21 /pmc/articles/PMC7279386/ /pubmed/32455630 http://dx.doi.org/10.3390/ijms21103641 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cardoso, Beatriz D.
Rodrigues, Ana Rita O.
Almeida, Bernardo G.
Amorim, Carlos O.
Amaral, Vítor S.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
title Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
title_full Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
title_fullStr Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
title_full_unstemmed Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
title_short Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
title_sort stealth magnetoliposomes based on calcium-substituted magnesium ferrite nanoparticles for curcumin transport and release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279386/
https://www.ncbi.nlm.nih.gov/pubmed/32455630
http://dx.doi.org/10.3390/ijms21103641
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