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Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections

Viruses have evolved different strategies to hijack subcellular organelles during their life cycle to produce robust infectious progeny. Successful viral reproduction requires the precise assembly of progeny virions from viral genomes, structural proteins, and membrane components. Such spatial and t...

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Detalles Bibliográficos
Autores principales: Ren, Shanhui, Ding, Chan, Sun, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279407/
https://www.ncbi.nlm.nih.gov/pubmed/32456258
http://dx.doi.org/10.3390/ijms21103689
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author Ren, Shanhui
Ding, Chan
Sun, Yingjie
author_facet Ren, Shanhui
Ding, Chan
Sun, Yingjie
author_sort Ren, Shanhui
collection PubMed
description Viruses have evolved different strategies to hijack subcellular organelles during their life cycle to produce robust infectious progeny. Successful viral reproduction requires the precise assembly of progeny virions from viral genomes, structural proteins, and membrane components. Such spatial and temporal separation of assembly reactions depends on accurate coordination among intracellular compartmentalization in multiple organelles. Here, we overview the rearrangement and morphology remodeling of virus-triggered intracellular organelles. Focus is given to the quality control of intracellular organelles, the hijacking of the modified organelle membranes by viruses, morphology remodeling for viral replication, and degradation of intracellular organelles by virus-triggered selective autophagy. Understanding the functional reprogram and morphological remodeling in the virus-organelle interplay can provide new insights into the development of broad-spectrum antiviral strategies.
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spelling pubmed-72794072020-06-17 Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections Ren, Shanhui Ding, Chan Sun, Yingjie Int J Mol Sci Review Viruses have evolved different strategies to hijack subcellular organelles during their life cycle to produce robust infectious progeny. Successful viral reproduction requires the precise assembly of progeny virions from viral genomes, structural proteins, and membrane components. Such spatial and temporal separation of assembly reactions depends on accurate coordination among intracellular compartmentalization in multiple organelles. Here, we overview the rearrangement and morphology remodeling of virus-triggered intracellular organelles. Focus is given to the quality control of intracellular organelles, the hijacking of the modified organelle membranes by viruses, morphology remodeling for viral replication, and degradation of intracellular organelles by virus-triggered selective autophagy. Understanding the functional reprogram and morphological remodeling in the virus-organelle interplay can provide new insights into the development of broad-spectrum antiviral strategies. MDPI 2020-05-23 /pmc/articles/PMC7279407/ /pubmed/32456258 http://dx.doi.org/10.3390/ijms21103689 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ren, Shanhui
Ding, Chan
Sun, Yingjie
Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections
title Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections
title_full Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections
title_fullStr Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections
title_full_unstemmed Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections
title_short Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections
title_sort morphology remodeling and selective autophagy of intracellular organelles during viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279407/
https://www.ncbi.nlm.nih.gov/pubmed/32456258
http://dx.doi.org/10.3390/ijms21103689
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