Cargando…

Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning

We present the analysis of the defective genetic pathways of the Late-Onset Alzheimer’s Disease (LOAD) compared to the Mild Cognitive Impairment (MCI) and Healthy Controls (HC) using different sampling methodologies. These algorithms sample the uncertainty space that is intrinsic to any kind of high...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Martínez, Juan Luis, Álvarez-Machancoses, Óscar, deAndrés-Galiana, Enrique J., Bea, Guillermina, Kloczkowski, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279419/ https://www.ncbi.nlm.nih.gov/pubmed/32438758 http://dx.doi.org/10.3390/ijms21103594

Ejemplares similares

Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19
por: deAndrés-Galiana, Enrique J., et al.
Publicado: (2022)

Robust Prediction of Single and Multiple Point Protein Mutations Stability Changes
por: Álvarez-Machancoses, Óscar, et al.
Publicado: (2019)

Robust Sampling of Defective Pathways in Multiple Myeloma
por: Fernández-Martínez, Juan Luis, et al.
Publicado: (2019)

Robust pathway sampling in phenotype prediction. Application to triple negative breast cancer
por: Cernea, Ana, et al.
Publicado: (2020)

On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine
por: Álvarez-Machancoses, Óscar, et al.
Publicado: (2020)

Addressing Noise and Estimating Uncertainty in Biomedical Data through the Exploration of Chemical Space
por: deAndrés-Galiana, Enrique J., et al.
Publicado: (2022)

Prediction of Protein Tertiary Structure via Regularized Template Classification Techniques
por: Álvarez-Machancoses, Óscar, et al.
Publicado: (2020)

Innovations in Genomics and Big Data Analytics for Personalized Medicine and Health Care: A Review
por: Hassan, Mubashir, et al.
Publicado: (2022)

Computational prognostic evaluation of Alzheimer’s drugs from FDA-approved database through structural conformational dynamics and drug repositioning approaches
por: Hassan, Mubashir, et al.
Publicado: (2023)

Supervised Classification by Filter Methods and Recursive Feature Elimination Predicts Risk of Radiotherapy-Related Fatigue in Patients with Prostate Cancer
por: Saligan, Leorey N, et al.
Publicado: (2014)

A predictive algorithm to identify genes that discriminate individuals with fibromyalgia syndrome diagnosis from healthy controls
por: Lukkahatai, Nada, et al.
Publicado: (2018)

mGluR5 mediates post-radiotherapy fatigue development in cancer patients
por: Feng, Li Rebekah, et al.
Publicado: (2018)

Exploration of Potential Ewing Sarcoma Drugs from FDA-Approved Pharmaceuticals through Computational Drug Repositioning, Pharmacogenomics, Molecular Docking, and MD Simulation Studies
por: Hassan, Mubashir, et al.
Publicado: (2022)

The Immunogenetics of Psoriasis and Implications for Drug Repositioning
por: Xu, Xuan, et al.
Publicado: (2017)

Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease?
por: Munafò, Antonio, et al.
Publicado: (2020)

Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
por: Huo, Yue, et al.
Publicado: (2018)

Therapeutic Implications of microRNAs in Depressive Disorders: A Review
por: Hassan, Mubashir, et al.
Publicado: (2022)

Drug Repositioning: An Opportunity to Develop Novel Treatments for Alzheimer’s Disease
por: Corbett, Anne, et al.
Publicado: (2013)

β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
por: Galeana-Ascencio, Roberto A., et al.
Publicado: (2023)

Nature’s Own Pharmacy: Mushroom-Based Chemical Scaffolds and Their Therapeutic Implications
por: Hassan, Mubashir, et al.
Publicado: (2023)

Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining
por: Zhang, Ming, et al.
Publicado: (2016)

A Proteotranscriptomic-Based Computational Drug-Repositioning Method for Alzheimer’s Disease
por: Lee, Soo Youn, et al.
Publicado: (2020)

Mechanistic insights into TNFR1/MADD death domains in Alzheimer’s disease through conformational molecular dynamic analysis
por: Hassan, Mubashir, et al.
Publicado: (2021)

Predictive Mathematical Models of the Short-Term and Long-Term Growth of the COVID-19 Pandemic
por: Fernández-Martínez, Juan Luis, et al.
Publicado: (2021)

Predictive mathematical models of the growth of the COVID-19 pandemic
por: Luis Fernández-Martínez, Juan, et al.
Publicado: (2022)

A robust defect detection method for syringe scale without positive samples
por: Wang, Xiaodong, et al.
Publicado: (2022)

Comparison of three mathematical models for COVID-19 prediction
por: Fernandez, Pelayo Martınez, et al.
Publicado: (2023)

Lip repositioning
por: Gaddale, Reetika, et al.
Publicado: (2014)

Surgical uprighting and repositioning of unerupted molars: Features and findings of a retrospective sample
por: Pippi, Roberto, et al.
Publicado: (2021)

DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer’s Disease
por: Chyr, Jacqueline, et al.
Publicado: (2022)

Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
por: Bayraktar, Abdulahad, et al.
Publicado: (2023)

Retrieval and repositioning of an embolized atrial septal defect closure device using a gooseneck snare
por: Batta, Akash, et al.
Publicado: (2021)

Particle Swarm Optimization and Uncertainty Assessment in Inverse Problems
por: Pallero, José L. G., et al.
Publicado: (2018)

ITRPCA: a new model for computational drug repositioning based on improved tensor robust principal component analysis
por: Yang, Mengyun, et al.
Publicado: (2023)

Drug reformulations and repositioning in the pharmaceutical industry and their impact on market access: regulatory implications
por: Murteira, Susana, et al.
Publicado: (2014)

Buccinator muscle repositioning
por: Baghele, Om N.
Publicado: (2012)

Repositioning Drugs for Psychiatry
por: Akhondzadeh, Shahin
Publicado: (2020)

Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning
por: Adasme, Melissa F., et al.
Publicado: (2020)

Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents
por: Zhu, Sha, et al.
Publicado: (2022)

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates
por: Vargas, D. M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_43i4o76r5968st6kcar50jjpss