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Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid

Caffeic acid is a natural antioxidant, largely distributed in plant tissues and food sources, possessing anti-inflammatory, antimicrobial, and anticarcinogenic properties. The object of this investigation was the development of a formulation for caffeic acid cutaneous administration. To this aim, ca...

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Autores principales: Sguizzato, Maddalena, Mariani, Paolo, Ferrara, Francesca, Drechsler, Markus, Hallan, Supandeep Singh, Huang, Nicolas, Simelière, Fanny, Khunti, Nikul, Cortesi, Rita, Marchetti, Nicola, Valacchi, Giuseppe, Esposito, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279527/
https://www.ncbi.nlm.nih.gov/pubmed/32443503
http://dx.doi.org/10.3390/nano10050961
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author Sguizzato, Maddalena
Mariani, Paolo
Ferrara, Francesca
Drechsler, Markus
Hallan, Supandeep Singh
Huang, Nicolas
Simelière, Fanny
Khunti, Nikul
Cortesi, Rita
Marchetti, Nicola
Valacchi, Giuseppe
Esposito, Elisabetta
author_facet Sguizzato, Maddalena
Mariani, Paolo
Ferrara, Francesca
Drechsler, Markus
Hallan, Supandeep Singh
Huang, Nicolas
Simelière, Fanny
Khunti, Nikul
Cortesi, Rita
Marchetti, Nicola
Valacchi, Giuseppe
Esposito, Elisabetta
author_sort Sguizzato, Maddalena
collection PubMed
description Caffeic acid is a natural antioxidant, largely distributed in plant tissues and food sources, possessing anti-inflammatory, antimicrobial, and anticarcinogenic properties. The object of this investigation was the development of a formulation for caffeic acid cutaneous administration. To this aim, caffeic acid has been loaded in solid lipid nanoparticles by hot homogenization and ultrasonication, obtaining aqueous dispersions with high drug encapsulation efficiency and 200 nm mean dimension, as assessed by photon correlation spectroscopy. With the aim to improve the consistence of the aqueous nanodispersions, different types of polymers have been considered. Particularly, poloxamer 407 and hyaluronic acid gels containing caffeic acid have been produced and characterized by X-ray and rheological analyses. A Franz cell study enabled to select poloxamer 407, being able to better control caffeic acid diffusion. Thus, a nanoparticulate gel has been produced by addition of poloxamer 407 to nanoparticle dispersions. Notably, caffeic acid diffusion from nanoparticulate gel was eight-fold slower with respect to the aqueous solution. In addition, the spreadability of nanoparticulate gel was suitable for cutaneous administration. Finally, the antioxidant effect of caffeic acid loaded in nanoparticulate gel has been demonstrated by ex-vivo evaluation on human skin explants exposed to cigarette smoke, suggesting a protective role exerted by the nanoparticles.
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spelling pubmed-72795272020-06-15 Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid Sguizzato, Maddalena Mariani, Paolo Ferrara, Francesca Drechsler, Markus Hallan, Supandeep Singh Huang, Nicolas Simelière, Fanny Khunti, Nikul Cortesi, Rita Marchetti, Nicola Valacchi, Giuseppe Esposito, Elisabetta Nanomaterials (Basel) Article Caffeic acid is a natural antioxidant, largely distributed in plant tissues and food sources, possessing anti-inflammatory, antimicrobial, and anticarcinogenic properties. The object of this investigation was the development of a formulation for caffeic acid cutaneous administration. To this aim, caffeic acid has been loaded in solid lipid nanoparticles by hot homogenization and ultrasonication, obtaining aqueous dispersions with high drug encapsulation efficiency and 200 nm mean dimension, as assessed by photon correlation spectroscopy. With the aim to improve the consistence of the aqueous nanodispersions, different types of polymers have been considered. Particularly, poloxamer 407 and hyaluronic acid gels containing caffeic acid have been produced and characterized by X-ray and rheological analyses. A Franz cell study enabled to select poloxamer 407, being able to better control caffeic acid diffusion. Thus, a nanoparticulate gel has been produced by addition of poloxamer 407 to nanoparticle dispersions. Notably, caffeic acid diffusion from nanoparticulate gel was eight-fold slower with respect to the aqueous solution. In addition, the spreadability of nanoparticulate gel was suitable for cutaneous administration. Finally, the antioxidant effect of caffeic acid loaded in nanoparticulate gel has been demonstrated by ex-vivo evaluation on human skin explants exposed to cigarette smoke, suggesting a protective role exerted by the nanoparticles. MDPI 2020-05-18 /pmc/articles/PMC7279527/ /pubmed/32443503 http://dx.doi.org/10.3390/nano10050961 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sguizzato, Maddalena
Mariani, Paolo
Ferrara, Francesca
Drechsler, Markus
Hallan, Supandeep Singh
Huang, Nicolas
Simelière, Fanny
Khunti, Nikul
Cortesi, Rita
Marchetti, Nicola
Valacchi, Giuseppe
Esposito, Elisabetta
Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
title Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
title_full Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
title_fullStr Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
title_full_unstemmed Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
title_short Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
title_sort nanoparticulate gels for cutaneous administration of caffeic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279527/
https://www.ncbi.nlm.nih.gov/pubmed/32443503
http://dx.doi.org/10.3390/nano10050961
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