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Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study

AIM: To determine the prevalence and factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic in Mulago Hospital. DESIGN: Cross-sectional observational study. SETTING: Mulago National Referral Hospital, Uganda, antenatal clinic. PARTICIPANTS: We randomly se...

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Autores principales: Kayondo, Simon Peter, Byamugisha, Josaphat K, Ntuyo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279652/
https://www.ncbi.nlm.nih.gov/pubmed/32499255
http://dx.doi.org/10.1136/bmjopen-2019-033043
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author Kayondo, Simon Peter
Byamugisha, Josaphat K
Ntuyo, Peter
author_facet Kayondo, Simon Peter
Byamugisha, Josaphat K
Ntuyo, Peter
author_sort Kayondo, Simon Peter
collection PubMed
description AIM: To determine the prevalence and factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic in Mulago Hospital. DESIGN: Cross-sectional observational study. SETTING: Mulago National Referral Hospital, Uganda, antenatal clinic. PARTICIPANTS: We randomly selected 340 pregnant women attending their first antenatal visit at Mulago Hospital antenatal clinic. PRIMARY OUTCOME: Hepatitis B surface antigen positivity. RESULTS: We recruited 340 participants, with a mean age of 27±5.7 years, and a median gravidity of 3. The prevalence of hepatitis B virus infection among pregnant women attending the antenatal clinic in Mulago Hospital, in our study, was 2.9% (95% CI 1.58% to 5.40%, n=10). Factors positively associated with hepatitis B virus infection were: marital status (adjusted OR (aOR)=11.37, p=0.002), having a hepatitis B positive family member (aOR=49.52, p<0.001) and having had a blood or body fluid splash to mucous membranes from a hepatitis B positive patient (aOR=61.69, p=0.015). Other factors such as age, socioeconomic status, number of sexual partners, HIV serostatus, piercing of ears and history of blood transfusion were not significantly associated with hepatitis B virus infection in this study. CONCLUSION: The prevalence of hepatitis B virus infection among pregnant women attending antenatal clinic in Mulago Hospital was of intermediate endemicity. We found that marital status, having a hepatitis B positive family member at home and having had a blood or body fluid splash to mucous membranes from a hepatitis B positive patient were independently associated with hepatitis B infection. Factors such as age, HIV status, history of blood transfusion, piercing of ears and social status were not associated with hepatitis B status in this study.
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spelling pubmed-72796522020-06-15 Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study Kayondo, Simon Peter Byamugisha, Josaphat K Ntuyo, Peter BMJ Open Obstetrics and Gynaecology AIM: To determine the prevalence and factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic in Mulago Hospital. DESIGN: Cross-sectional observational study. SETTING: Mulago National Referral Hospital, Uganda, antenatal clinic. PARTICIPANTS: We randomly selected 340 pregnant women attending their first antenatal visit at Mulago Hospital antenatal clinic. PRIMARY OUTCOME: Hepatitis B surface antigen positivity. RESULTS: We recruited 340 participants, with a mean age of 27±5.7 years, and a median gravidity of 3. The prevalence of hepatitis B virus infection among pregnant women attending the antenatal clinic in Mulago Hospital, in our study, was 2.9% (95% CI 1.58% to 5.40%, n=10). Factors positively associated with hepatitis B virus infection were: marital status (adjusted OR (aOR)=11.37, p=0.002), having a hepatitis B positive family member (aOR=49.52, p<0.001) and having had a blood or body fluid splash to mucous membranes from a hepatitis B positive patient (aOR=61.69, p=0.015). Other factors such as age, socioeconomic status, number of sexual partners, HIV serostatus, piercing of ears and history of blood transfusion were not significantly associated with hepatitis B virus infection in this study. CONCLUSION: The prevalence of hepatitis B virus infection among pregnant women attending antenatal clinic in Mulago Hospital was of intermediate endemicity. We found that marital status, having a hepatitis B positive family member at home and having had a blood or body fluid splash to mucous membranes from a hepatitis B positive patient were independently associated with hepatitis B infection. Factors such as age, HIV status, history of blood transfusion, piercing of ears and social status were not associated with hepatitis B status in this study. BMJ Publishing Group 2020-06-03 /pmc/articles/PMC7279652/ /pubmed/32499255 http://dx.doi.org/10.1136/bmjopen-2019-033043 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Obstetrics and Gynaecology
Kayondo, Simon Peter
Byamugisha, Josaphat K
Ntuyo, Peter
Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study
title Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study
title_full Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study
title_fullStr Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study
title_full_unstemmed Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study
title_short Prevalence of hepatitis B virus infection and associated risk factors among pregnant women attending antenatal clinic in Mulago Hospital, Uganda: a cross-sectional study
title_sort prevalence of hepatitis b virus infection and associated risk factors among pregnant women attending antenatal clinic in mulago hospital, uganda: a cross-sectional study
topic Obstetrics and Gynaecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279652/
https://www.ncbi.nlm.nih.gov/pubmed/32499255
http://dx.doi.org/10.1136/bmjopen-2019-033043
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