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Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol
INTRODUCTION: Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer’s disease (AD). Damage to the precuneus through focal brain injury is associated with impaired visually guided reaching, particularly for o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279656/ https://www.ncbi.nlm.nih.gov/pubmed/32503870 http://dx.doi.org/10.1136/bmjopen-2019-035021 |
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author | Mitchell, Alexandra G McIntosh, Robert D Rossit, Stephanie Hornberger, Michael Pal, Suvankar |
author_facet | Mitchell, Alexandra G McIntosh, Robert D Rossit, Stephanie Hornberger, Michael Pal, Suvankar |
author_sort | Mitchell, Alexandra G |
collection | PubMed |
description | INTRODUCTION: Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer’s disease (AD). Damage to the precuneus through focal brain injury is associated with impaired visually guided reaching, particularly for objects in peripheral vision. This raises the hypothesis that peripheral misreaching may be detectable in patients with prodromal AD. The aim of this study is to assess the frequency and severity of peripheral misreaching in patients with mild cognitive impairment (MCI) and AD. METHODS AND ANALYSIS: Patients presenting with amnestic MCI, mild-to-moderate AD and healthy older-adult controls will be tested (target N=24 per group). Peripheral misreaching will be assessed using two set-ups: a tablet-based task of lateral reaching and motion-tracked radial reaching (in depth). There are two versions of each task, one where participants can look directly at targets (free reaching), another wheren they must maintain central fixation (peripheral reaching). All tasks will be conducted first on their dominant, and then their non-dominant side. For each combination of task and side, a Peripheral Misreaching Index (PMI) will be calculated as the increase in absolute reaching error between free and peripheral reaching. Each patient will be classified as showing peripheral misreaching if their PMI is significantly abnormal, by comparison to control performance, on either side of space. We will then test whether the frequency of peripheral misreaching exceeds the chance level in each patient group and compare the overall severity of misreaching between groups. ETHICS AND DISSEMINATION: Ethical approval was provided by the National Health Service (NHS) East of England, Cambridge Central Research Ethics Committee (REC 19/EE/0170). The results of this study will be published in a peer-reviewed journal and presented at academic conferences. |
format | Online Article Text |
id | pubmed-7279656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-72796562020-06-15 Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol Mitchell, Alexandra G McIntosh, Robert D Rossit, Stephanie Hornberger, Michael Pal, Suvankar BMJ Open Neurology INTRODUCTION: Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer’s disease (AD). Damage to the precuneus through focal brain injury is associated with impaired visually guided reaching, particularly for objects in peripheral vision. This raises the hypothesis that peripheral misreaching may be detectable in patients with prodromal AD. The aim of this study is to assess the frequency and severity of peripheral misreaching in patients with mild cognitive impairment (MCI) and AD. METHODS AND ANALYSIS: Patients presenting with amnestic MCI, mild-to-moderate AD and healthy older-adult controls will be tested (target N=24 per group). Peripheral misreaching will be assessed using two set-ups: a tablet-based task of lateral reaching and motion-tracked radial reaching (in depth). There are two versions of each task, one where participants can look directly at targets (free reaching), another wheren they must maintain central fixation (peripheral reaching). All tasks will be conducted first on their dominant, and then their non-dominant side. For each combination of task and side, a Peripheral Misreaching Index (PMI) will be calculated as the increase in absolute reaching error between free and peripheral reaching. Each patient will be classified as showing peripheral misreaching if their PMI is significantly abnormal, by comparison to control performance, on either side of space. We will then test whether the frequency of peripheral misreaching exceeds the chance level in each patient group and compare the overall severity of misreaching between groups. ETHICS AND DISSEMINATION: Ethical approval was provided by the National Health Service (NHS) East of England, Cambridge Central Research Ethics Committee (REC 19/EE/0170). The results of this study will be published in a peer-reviewed journal and presented at academic conferences. BMJ Publishing Group 2020-06-04 /pmc/articles/PMC7279656/ /pubmed/32503870 http://dx.doi.org/10.1136/bmjopen-2019-035021 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Neurology Mitchell, Alexandra G McIntosh, Robert D Rossit, Stephanie Hornberger, Michael Pal, Suvankar Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol |
title | Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol |
title_full | Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol |
title_fullStr | Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol |
title_full_unstemmed | Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol |
title_short | Assessment of visually guided reaching in prodromal Alzheimer’s disease: a cross-sectional study protocol |
title_sort | assessment of visually guided reaching in prodromal alzheimer’s disease: a cross-sectional study protocol |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279656/ https://www.ncbi.nlm.nih.gov/pubmed/32503870 http://dx.doi.org/10.1136/bmjopen-2019-035021 |
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