Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

Microglial dysfunction is a key pathological feature of Alzheimer's disease (AD), but little is known about proteome-wide changes in microglia during the course of AD and their functional consequences. Here, we performed an in-depth and time-resolved proteomic characterization of microglia in t...

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Detalles Bibliográficos
Autores principales: Sebastian Monasor, Laura, Müller, Stephan A, Colombo, Alessio Vittorio, Tanrioever, Gaye, König, Jasmin, Roth, Stefan, Liesz, Arthur, Berghofer, Anna, Piechotta, Anke, Prestel, Matthias, Saito, Takashi, Saido, Takaomi C, Herms, Jochen, Willem, Michael, Haass, Christian, Lichtenthaler, Stefan F, Tahirovic, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279888/
https://www.ncbi.nlm.nih.gov/pubmed/32510331
http://dx.doi.org/10.7554/eLife.54083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279888/
https://www.ncbi.nlm.nih.gov/pubmed/32510331
http://dx.doi.org/10.7554/eLife.54083

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