Cargando…

Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

BACKGROUND AND PURPOSE: GPCRs can signal through both G proteins and β‐arrestin2. For the μ‐opioid receptor, early experimental evidence from a single study suggested that G protein signalling mediates analgesia, whereas β‐arrestin2 signalling mediates respiratory depression and constipation. Conseq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kliewer, Andrea, Gillis, Alexander, Hill, Rob, Schmiedel, Frank, Bailey, Chris, Kelly, Eamonn, Henderson, Graeme, Christie, Macdonald J., Schulz, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280004/ https://www.ncbi.nlm.nih.gov/pubmed/32052419 http://dx.doi.org/10.1111/bph.15004

Ejemplares similares

Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine
por: Hill, Rob, et al.
Publicado: (2016)

Role of Acetaldehyde in Ethanol Reversal of Tolerance to Morphine-Induced Respiratory Depression in Mice
por: Hill, Rob, et al.
Publicado: (2022)

The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception
por: Hill, Rob, et al.
Publicado: (2018)

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
por: Kliewer, A., et al.
Publicado: (2019)

miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats
por: Wang, Jian, et al.
Publicado: (2016)

Improvement of Morphine-Mediated Analgesia by Inhibition of β-Arrestin 2 Expression in Mice Periaqueductal Gray Matter
por: Li, Yuting, et al.
Publicado: (2009)

Morphine dependence in single enteric neurons from the mouse colon requires deletion of β‐arrestin2
por: Smith, Tricia H., et al.
Publicado: (2014)

ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression
por: Bachmutsky, Iris, et al.
Publicado: (2021)

ABCC3 Genetic Variants are Associated with Postoperative Morphine-induced Respiratory Depression and Morphine Pharmacokinetics in Children
por: Chidambaran, Vidya, et al.
Publicado: (2016)

GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
por: Drube, J., et al.
Publicado: (2022)

Arrestin‐independent constitutive endocytosis of GPR125/ADGRA3
por: Spiess, Katja, et al.
Publicado: (2019)

Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src
por: Bull, Fiona A., et al.
Publicado: (2017)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2
por: Wu, Xian-Ping, et al.
Publicado: (2018)

Aspiration Pneumonitis Caused by Delayed Respiratory Depression Following Intrathecal Morphine Administration
por: Whang, Bo Young, et al.
Publicado: (2012)

Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart
por: Lymperopoulos, Anastasios, et al.
Publicado: (2019)

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
por: Daly, Carole, et al.
Publicado: (2023)

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
por: Daly, Carole, et al.
Publicado: (2023)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins
por: Kocan, Martina, et al.
Publicado: (2011)

ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and β-Arrestin Recruitment
por: Sánchez-Fernández, Guzmán, et al.
Publicado: (2013)

The single nucleotide β -arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
por: ŞENSOY, Özge
Publicado: (2020)

On the origins of arrestin and rhodopsin
por: Alvarez, Carlos E
Publicado: (2008)

α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis
por: Prosser, Derek C., et al.
Publicado: (2015)

Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis
por: Bergese, Sergio, et al.
Publicado: (2020)

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension
por: Willets, Jonathon M., et al.
Publicado: (2015)

A Novel G Protein–Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain
por: Conibear, Alexandra E., et al.
Publicado: (2020)

Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands
por: Marsango, Sara, et al.
Publicado: (2022)

μ-Opioid receptor desensitization: homologous or heterologous?
por: Llorente, Javier, et al.
Publicado: (2012)

Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats
por: Morgan, Michael M., et al.
Publicado: (2009)

β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
por: Liu, Yang, et al.
Publicado: (2022)

c-Src Regulates Akt Signaling in Response to Ghrelin via β-Arrestin Signaling-Independent and -Dependent Mechanisms
por: Lodeiro, Maria, et al.
Publicado: (2009)

Multifaceted role of β-arrestins in inflammation and disease
por: Sharma, Deepika, et al.
Publicado: (2015)

β-Arrestin-Dependent Deactivation of Mouse Melanopsin
por: Cameron, Evan G., et al.
Publicado: (2014)

Phosphorylation of β-arrestin2 at Thr(383) by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs
por: Cassier, Elisabeth, et al.
Publicado: (2017)

β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4
por: D’Agostino, Gianluca, et al.
Publicado: (2020)

How Arrestins and GRKs Regulate the Function of Long Chain Fatty Acid Receptors
por: Alharbi, Abdulrahman G., et al.
Publicado: (2022)

KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer
por: Kim, Minsuh, et al.
Publicado: (2016)

Glutamate transporters: The arrestin connection
por: Zafra, Francisco, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jipr3mrrvsa3u36ev5g712tp0g