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Endobronchial tuberculosis polyps

Endobronchial tuberculosis (TB) is an uncommon manifestation of Mycobacterium tuberculosis. We report a case of endobronchial TB polyps in a patient from India presenting with cough, loss of weight and night sweats. Computed tomography chest revealed enlarged mediastinal lymph nodes, endobronchial i...

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Detalles Bibliográficos
Autores principales: Yu, Christiaan, Foo, Chuan Tai, Aung, Ar Kar, Joosten, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280025/
https://www.ncbi.nlm.nih.gov/pubmed/32528684
http://dx.doi.org/10.1002/rcr2.595
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author Yu, Christiaan
Foo, Chuan Tai
Aung, Ar Kar
Joosten, Simon A.
author_facet Yu, Christiaan
Foo, Chuan Tai
Aung, Ar Kar
Joosten, Simon A.
author_sort Yu, Christiaan
collection PubMed
description Endobronchial tuberculosis (TB) is an uncommon manifestation of Mycobacterium tuberculosis. We report a case of endobronchial TB polyps in a patient from India presenting with cough, loss of weight and night sweats. Computed tomography chest revealed enlarged mediastinal lymph nodes, endobronchial invasion, and nodular infiltrates in the right lower lobe. Flexible bronchoscopy revealed two endobronchial polyps at the carina and left main bronchus which were biopsied. Histopathology showed non‐caseating granulomas. Both the biopsy and bronchial washings did not identify acid‐fast bacilli on Ziehl‐Neelsen stain and had negative TB complex DNA polymerase chain reaction. One month after bronchoscopy, M. tuberculosis was cultured from the bronchial washings. Following six months of TB treatment, there was full resolution of symptoms and significant radiological improvement. We highlight the diagnostic challenges in endobronchial TB which may impact on the timely institution of treatment.
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spelling pubmed-72800252020-06-10 Endobronchial tuberculosis polyps Yu, Christiaan Foo, Chuan Tai Aung, Ar Kar Joosten, Simon A. Respirol Case Rep Case Reports Endobronchial tuberculosis (TB) is an uncommon manifestation of Mycobacterium tuberculosis. We report a case of endobronchial TB polyps in a patient from India presenting with cough, loss of weight and night sweats. Computed tomography chest revealed enlarged mediastinal lymph nodes, endobronchial invasion, and nodular infiltrates in the right lower lobe. Flexible bronchoscopy revealed two endobronchial polyps at the carina and left main bronchus which were biopsied. Histopathology showed non‐caseating granulomas. Both the biopsy and bronchial washings did not identify acid‐fast bacilli on Ziehl‐Neelsen stain and had negative TB complex DNA polymerase chain reaction. One month after bronchoscopy, M. tuberculosis was cultured from the bronchial washings. Following six months of TB treatment, there was full resolution of symptoms and significant radiological improvement. We highlight the diagnostic challenges in endobronchial TB which may impact on the timely institution of treatment. John Wiley & Sons, Ltd 2020-06-08 /pmc/articles/PMC7280025/ /pubmed/32528684 http://dx.doi.org/10.1002/rcr2.595 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Yu, Christiaan
Foo, Chuan Tai
Aung, Ar Kar
Joosten, Simon A.
Endobronchial tuberculosis polyps
title Endobronchial tuberculosis polyps
title_full Endobronchial tuberculosis polyps
title_fullStr Endobronchial tuberculosis polyps
title_full_unstemmed Endobronchial tuberculosis polyps
title_short Endobronchial tuberculosis polyps
title_sort endobronchial tuberculosis polyps
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280025/
https://www.ncbi.nlm.nih.gov/pubmed/32528684
http://dx.doi.org/10.1002/rcr2.595
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