Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

In this report, a series of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives were designed to explore the hydrophobic channel of the non-nucleoside reverse transcriptase inhibitors binding pocket (NNIBP) by incorporating an aromatic moiety to the left wing of the lead K-5a2. The n...

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Detalles Bibliográficos
Autores principales: Kang, Dongwei, Feng, Da, Ginex, Tiziana, Zou, Jinmi, Wei, Fenju, Zhao, Tong, Huang, Boshi, Sun, Yanying, Desta, Samuel, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280082/
https://www.ncbi.nlm.nih.gov/pubmed/32528834
http://dx.doi.org/10.1016/j.apsb.2019.08.013

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