Accelerated instability testing reveals quantitative mass spectrometry overcomes specimen storage limitations associated with PD-L1 immunohistochemistry

Immunohistochemistry (IHC) using formalin-fixed, paraffin embedded (FFPE) tissue is limited by epitope masking, posttranslational modification and immunoreactivity loss that occurs in stored tissue by poorly characterized mechanisms. Conformational epitopes recognized by many programmed-death-ligand...

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Detalles Bibliográficos
Autores principales: Haragan, Alexander, Liebler, Daniel C., Das, Dimple M., Soper, Michael D., Morrison, Ryan D., Slebos, Robbert J. C., Ackermann, Bradley L., Fill, Jeff A., Schade, Andrew E., Gosney, John R., Gruver, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280177/
https://www.ncbi.nlm.nih.gov/pubmed/31896815
http://dx.doi.org/10.1038/s41374-019-0366-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280177/
https://www.ncbi.nlm.nih.gov/pubmed/31896815
http://dx.doi.org/10.1038/s41374-019-0366-y

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