Cargando…

Deficits in olfactory sensitivity in a mouse model of Parkinson’s disease revealed by plethysmography of odor-evoked sniffing

Hyposmia is evident in over 90% of Parkinson’s disease (PD) patients. A characteristic of PD is intraneuronal deposits composed in part of α-synuclein fibrils. Based on the analysis of post-mortem PD patients, Braak and colleagues suggested that early in the disease α-synuclein pathology is present...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Michaela E., Bergkvist, Liza, Mercado, Gabriela, Stetzik, Lucas, Meyerdirk, Lindsay, Wolfrum, Emily, Madaj, Zachary, Brundin, Patrik, Wesson, Daniel W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280205/ https://www.ncbi.nlm.nih.gov/pubmed/32514004 http://dx.doi.org/10.1038/s41598-020-66201-8

Ejemplares similares

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
por: Rey, Nolwen L., et al.
Publicado: (2019)

Sniffing Fast: Paradoxical Effects on Odor Concentration Discrimination at the Levels of Olfactory Bulb Output and Behavior
por: Jordan, Rebecca, et al.
Publicado: (2018)

Sniffing out olfactory reference syndrome
por: Thomas, Eileen, et al.
Publicado: (2017)

A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model
por: Stetzik, Lucas, et al.
Publicado: (2022)

A Physiological Increase of Insulin in the Olfactory Bulb Decreases Detection of a Learned Aversive Odor and Abolishes Food Odor-Induced Sniffing Behavior in Rats
por: Aimé, Pascaline, et al.
Publicado: (2012)

Repeated exposure to odors induces affective habituation of perception and sniffing
por: Ferdenzi, Camille, et al.
Publicado: (2014)

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
por: Rey, Nolwen L., et al.
Publicado: (2016)

Characterization of odor-evoked neural activity in the olfactory peduncle
por: Cousens, Graham A.
Publicado: (2020)

Mirror Sniffing: Humans Mimic Olfactory Sampling Behavior
por: Arzi, Anat, et al.
Publicado: (2014)

Sniffing out Ca(2+) signaling in olfactory cilia
por: Short, Ben
Publicado: (2023)

Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila
por: Cao, Li-Hui, et al.
Publicado: (2017)

Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes
por: Oh, Yunkwang, et al.
Publicado: (2021)

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
por: George, Sonia, et al.
Publicado: (2019)

Odor-evoked increases in olfactory bulb mitral cell spiking variability
por: Ly, Cheng, et al.
Publicado: (2021)

Faster, Deeper, Better: The Impact of Sniffing Modulation on Bulbar Olfactory Processing
por: Esclassan, Frédéric, et al.
Publicado: (2012)

Olfactory Ensheathing Cells for Spinal Cord Injury: Sniffing Out the Issues
por: Yao, R., et al.
Publicado: (2018)

Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb
por: Korshunov, Kirill S., et al.
Publicado: (2020)

Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb
por: Liu, Annie, et al.
Publicado: (2017)

Neuropeptide feedback modifies odor-evoked dynamics in C. elegans olfactory neurons
por: Chalasani, Sreekanth H., et al.
Publicado: (2010)

Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli
por: Furudono, Yuichi, et al.
Publicado: (2013)

Parallel Odor Processing by Two Anatomically Distinct Olfactory Bulb Target Structures
por: Payton, Colleen A., et al.
Publicado: (2012)

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
por: Rey, Nolwen L., et al.
Publicado: (2016)

Sniffing out cognitive decline in patients with and without evidence of dopaminergic deficit
por: Lopez, Francesca V., et al.
Publicado: (2019)

Correction: Parallel Odor Processing by Two Anatomically Distinct Olfactory Bulb Target Structures
por: Payton, Colleen A., et al.
Publicado: (2012)

Odor-evoked layer-specific fMRI activities in the awake mouse olfactory bulb
por: Poplawsky, Alexander John, et al.
Publicado: (2023)

Urinary tract infections trigger synucleinopathy via the innate immune response
por: Peelaerts, Wouter, et al.
Publicado: (2023)

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term
por: Rey, Nolwen L., et al.
Publicado: (2017)

Rasagiline Ameliorates Olfactory Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease
por: Petit, Géraldine H., et al.
Publicado: (2013)

Olfactory tubercle stimulation alters odor preference behavior and recruits forebrain reward and motivational centers
por: FitzGerald, Brynn J., et al.
Publicado: (2014)

Ethereal packet sniffing
por: Orebaugh, Angela, et al.
Publicado: (2004)

Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
por: Chery, Romain, et al.
Publicado: (2011)

Modulatory Effects of Sex Steroids Progesterone and Estradiol on Odorant Evoked Responses in Olfactory Receptor Neurons
por: Kanageswaran, Ninthujah, et al.
Publicado: (2016)

Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons
por: Zak, Joseph D., et al.
Publicado: (2018)

Olfactory Dysfunction as a Global Biomarker for Sniffing out Alzheimer’s Disease: A Meta-Analysis
por: Kotecha, Alisha M., et al.
Publicado: (2018)

Distinct Characteristics of Odor-evoked Calcium and Electrophysiological Signals in Mitral/Tufted Cells in the Mouse Olfactory Bulb
por: Xu, Han, et al.
Publicado: (2021)

The sniffing bead system, an olfactory dysfunction screening tool for geriatric subjects: a cross-sectional study
por: Min, Hyun Jin, et al.
Publicado: (2021)

Sniffing Out the Right Address
por: Jones, Rachel
Publicado: (2008)

Pneumorachis after cocaine sniffing
por: Challita, S., et al.
Publicado: (2014)

The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice
por: Montaner, Mireia, et al.
Publicado: (2023)

Implantable Impedance Plethysmography
por: Theodor, Michael, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3h28tvs5r607kdrd2v4je4gkso