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Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice

Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer’s disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ...

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Detalles Bibliográficos
Autores principales:	He, Zitian, Yang, Yunjie, Xing, Zhiwei, Zuo, Zejie, Wang, Rui, Gu, Huaiyu, Qi, Fangfang, Yao, Zhibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280212/ https://www.ncbi.nlm.nih.gov/pubmed/32514180 http://dx.doi.org/10.1038/s41419-020-2644-4

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