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A heritable profile of six miRNAs in autistic patients and mouse models

Autism spectrum disorder (ASD) is a group of developmental pathologies that impair social communication and cause repetitive behaviors. The suggested roles of noncoding RNAs in pathology led us to perform a comparative analysis of the microRNAs expressed in the serum of human ASD patients. The analy...

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Autores principales: Ozkul, Yusuf, Taheri, Serpil, Bayram, Kezban Korkmaz, Sener, Elif Funda, Mehmetbeyoglu, Ecmel, Öztop, Didem Behice, Aybuga, Fatma, Tufan, Esra, Bayram, Arslan, Dolu, Nazan, Zararsiz, Gokmen, Kianmehr, Leila, Beyaz, Feyzullah, Doganyigit, Züleyha, Cuzin, François, Rassoulzadegan, Minoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280218/
https://www.ncbi.nlm.nih.gov/pubmed/32514154
http://dx.doi.org/10.1038/s41598-020-65847-8
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author Ozkul, Yusuf
Taheri, Serpil
Bayram, Kezban Korkmaz
Sener, Elif Funda
Mehmetbeyoglu, Ecmel
Öztop, Didem Behice
Aybuga, Fatma
Tufan, Esra
Bayram, Arslan
Dolu, Nazan
Zararsiz, Gokmen
Kianmehr, Leila
Beyaz, Feyzullah
Doganyigit, Züleyha
Cuzin, François
Rassoulzadegan, Minoo
author_facet Ozkul, Yusuf
Taheri, Serpil
Bayram, Kezban Korkmaz
Sener, Elif Funda
Mehmetbeyoglu, Ecmel
Öztop, Didem Behice
Aybuga, Fatma
Tufan, Esra
Bayram, Arslan
Dolu, Nazan
Zararsiz, Gokmen
Kianmehr, Leila
Beyaz, Feyzullah
Doganyigit, Züleyha
Cuzin, François
Rassoulzadegan, Minoo
author_sort Ozkul, Yusuf
collection PubMed
description Autism spectrum disorder (ASD) is a group of developmental pathologies that impair social communication and cause repetitive behaviors. The suggested roles of noncoding RNAs in pathology led us to perform a comparative analysis of the microRNAs expressed in the serum of human ASD patients. The analysis of a cohort of 45 children with ASD revealed that six microRNAs (miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. A similar but less pronounced decrease was registered in the clinically unaffected parents of the sick children and in their siblings but never in any genetically unrelated control. Results consistent with these observations were obtained in the blood, hypothalamus and sperm of two of the established mouse models of ASD: valproic acid-treated animals and Cc2d1a(+/−) heterozygotes. In both instances, the same characteristic miRNA profile was evidenced in the affected individuals and inherited together with disease symptoms in the progeny of crosses with healthy animals. The consistent association of these genetic regulatory changes with the disease provides a starting point for evaluating the changes in the activity of the target genes and, thus, the underlying mechanism(s). From the applied societal and medical perspectives, once properly confirmed in large cohorts, these observations provide tools for the very early identification of affected children and progenitors.
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spelling pubmed-72802182020-06-15 A heritable profile of six miRNAs in autistic patients and mouse models Ozkul, Yusuf Taheri, Serpil Bayram, Kezban Korkmaz Sener, Elif Funda Mehmetbeyoglu, Ecmel Öztop, Didem Behice Aybuga, Fatma Tufan, Esra Bayram, Arslan Dolu, Nazan Zararsiz, Gokmen Kianmehr, Leila Beyaz, Feyzullah Doganyigit, Züleyha Cuzin, François Rassoulzadegan, Minoo Sci Rep Article Autism spectrum disorder (ASD) is a group of developmental pathologies that impair social communication and cause repetitive behaviors. The suggested roles of noncoding RNAs in pathology led us to perform a comparative analysis of the microRNAs expressed in the serum of human ASD patients. The analysis of a cohort of 45 children with ASD revealed that six microRNAs (miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. A similar but less pronounced decrease was registered in the clinically unaffected parents of the sick children and in their siblings but never in any genetically unrelated control. Results consistent with these observations were obtained in the blood, hypothalamus and sperm of two of the established mouse models of ASD: valproic acid-treated animals and Cc2d1a(+/−) heterozygotes. In both instances, the same characteristic miRNA profile was evidenced in the affected individuals and inherited together with disease symptoms in the progeny of crosses with healthy animals. The consistent association of these genetic regulatory changes with the disease provides a starting point for evaluating the changes in the activity of the target genes and, thus, the underlying mechanism(s). From the applied societal and medical perspectives, once properly confirmed in large cohorts, these observations provide tools for the very early identification of affected children and progenitors. Nature Publishing Group UK 2020-06-09 /pmc/articles/PMC7280218/ /pubmed/32514154 http://dx.doi.org/10.1038/s41598-020-65847-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ozkul, Yusuf
Taheri, Serpil
Bayram, Kezban Korkmaz
Sener, Elif Funda
Mehmetbeyoglu, Ecmel
Öztop, Didem Behice
Aybuga, Fatma
Tufan, Esra
Bayram, Arslan
Dolu, Nazan
Zararsiz, Gokmen
Kianmehr, Leila
Beyaz, Feyzullah
Doganyigit, Züleyha
Cuzin, François
Rassoulzadegan, Minoo
A heritable profile of six miRNAs in autistic patients and mouse models
title A heritable profile of six miRNAs in autistic patients and mouse models
title_full A heritable profile of six miRNAs in autistic patients and mouse models
title_fullStr A heritable profile of six miRNAs in autistic patients and mouse models
title_full_unstemmed A heritable profile of six miRNAs in autistic patients and mouse models
title_short A heritable profile of six miRNAs in autistic patients and mouse models
title_sort heritable profile of six mirnas in autistic patients and mouse models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280218/
https://www.ncbi.nlm.nih.gov/pubmed/32514154
http://dx.doi.org/10.1038/s41598-020-65847-8
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