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Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization
Our recently developed ensilication approach can physically stabilize proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Biopharmaceuticals, e.g. liquid-formulated vaccines w...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280242/ https://www.ncbi.nlm.nih.gov/pubmed/32513957 http://dx.doi.org/10.1038/s41598-020-65876-3 |