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Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization

Our recently developed ensilication approach can physically stabilize proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Biopharmaceuticals, e.g. liquid-formulated vaccines w...

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Detalles Bibliográficos
Autores principales:	Doekhie, A., Dattani, R., Chen, Y-C., Yang, Y., Smith, A., Silve, A. P., Koumanov, F., Wells, S. A., Edler, K. J., Marchbank, K. J., Elsen, J. M. H. van den, Sartbaeva, A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280242/ https://www.ncbi.nlm.nih.gov/pubmed/32513957 http://dx.doi.org/10.1038/s41598-020-65876-3

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