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Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood

OBJECTIVES: Famine exposure in early life was associated with type 2 diabetes, non-alcoholic fatty liver disease and metabolic syndrome, etc. But evidence in early famine exposure and insulin resistance and beta cell dysfunction were limited. We aimed to investigate whether the association existed b...

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Autores principales: Wang, Yuying, Wan, Heng, Chen, Chi, Chen, Yi, Xia, Fangzhen, Han, Bing, Li, Qin, Wang, Ningjian, Lu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280514/
https://www.ncbi.nlm.nih.gov/pubmed/32514025
http://dx.doi.org/10.1038/s41387-020-0121-x
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author Wang, Yuying
Wan, Heng
Chen, Chi
Chen, Yi
Xia, Fangzhen
Han, Bing
Li, Qin
Wang, Ningjian
Lu, Yingli
author_facet Wang, Yuying
Wan, Heng
Chen, Chi
Chen, Yi
Xia, Fangzhen
Han, Bing
Li, Qin
Wang, Ningjian
Lu, Yingli
author_sort Wang, Yuying
collection PubMed
description OBJECTIVES: Famine exposure in early life was associated with type 2 diabetes, non-alcoholic fatty liver disease and metabolic syndrome, etc. But evidence in early famine exposure and insulin resistance and beta cell dysfunction were limited. We aimed to investigate whether the association existed between famine exposure in early life and beta cell dysfunction and insulin resistance in adulthood. METHODS: In all, 7912 non-diabetic participants were included in this study, based on SPECT-China study. Participants with fetal or childhood famine exposure (birth year 1949–1962) were exposure group. Insulin resistance was estimated by the homeostasis model assessment index of insulin resistance (HOMA-IR). Beta cell function, represented by insulin secretion, was estimated by the disposition index. The associations of famine exposure with HOMA-IR and disposition index were assessed via linear regression. RESULTS: In men, we did not observe a significant association between early life famine exposure and ln(HOMA-IR) in all three models (P > 0.05 for all). However, in women, early life famine exposure were found to have significant association with ln(HOMA-IR) after adjustments for urbanization, severity of famine exposure, current smoker, waist circumference, hypertension, and dyslipidemia (unstandardized coefficients 0.055, 95% confidence interval 0.021, 0.088, P = 0.001). Early life famine exposure was observed to be negatively associated with ln(disposition index) after adjustments for the above potential confounders, both in men (model 3: unstandardized coefficients −0.042, 95% confidence interval −0.072,−0.012, P = 0.006) and women (model 3: unstandardized coefficients −0.033, 95% confidence interval −0.058,−0.009, P = 0.008). CONCLUSIONS: In conclusion, exposure to famine in fetal- and childhood- life period is associated with beta cell dysfunction in males and females without diabetes, but early life famine exposure was only associated with insulin resistance in non-diabetic females. These results indicate that malnutrition in early life period may offer a modifiable factor for type 2 diabetes development.
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spelling pubmed-72805142020-06-16 Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood Wang, Yuying Wan, Heng Chen, Chi Chen, Yi Xia, Fangzhen Han, Bing Li, Qin Wang, Ningjian Lu, Yingli Nutr Diabetes Article OBJECTIVES: Famine exposure in early life was associated with type 2 diabetes, non-alcoholic fatty liver disease and metabolic syndrome, etc. But evidence in early famine exposure and insulin resistance and beta cell dysfunction were limited. We aimed to investigate whether the association existed between famine exposure in early life and beta cell dysfunction and insulin resistance in adulthood. METHODS: In all, 7912 non-diabetic participants were included in this study, based on SPECT-China study. Participants with fetal or childhood famine exposure (birth year 1949–1962) were exposure group. Insulin resistance was estimated by the homeostasis model assessment index of insulin resistance (HOMA-IR). Beta cell function, represented by insulin secretion, was estimated by the disposition index. The associations of famine exposure with HOMA-IR and disposition index were assessed via linear regression. RESULTS: In men, we did not observe a significant association between early life famine exposure and ln(HOMA-IR) in all three models (P > 0.05 for all). However, in women, early life famine exposure were found to have significant association with ln(HOMA-IR) after adjustments for urbanization, severity of famine exposure, current smoker, waist circumference, hypertension, and dyslipidemia (unstandardized coefficients 0.055, 95% confidence interval 0.021, 0.088, P = 0.001). Early life famine exposure was observed to be negatively associated with ln(disposition index) after adjustments for the above potential confounders, both in men (model 3: unstandardized coefficients −0.042, 95% confidence interval −0.072,−0.012, P = 0.006) and women (model 3: unstandardized coefficients −0.033, 95% confidence interval −0.058,−0.009, P = 0.008). CONCLUSIONS: In conclusion, exposure to famine in fetal- and childhood- life period is associated with beta cell dysfunction in males and females without diabetes, but early life famine exposure was only associated with insulin resistance in non-diabetic females. These results indicate that malnutrition in early life period may offer a modifiable factor for type 2 diabetes development. Nature Publishing Group UK 2020-06-08 /pmc/articles/PMC7280514/ /pubmed/32514025 http://dx.doi.org/10.1038/s41387-020-0121-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Yuying
Wan, Heng
Chen, Chi
Chen, Yi
Xia, Fangzhen
Han, Bing
Li, Qin
Wang, Ningjian
Lu, Yingli
Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
title Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
title_full Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
title_fullStr Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
title_full_unstemmed Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
title_short Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
title_sort association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280514/
https://www.ncbi.nlm.nih.gov/pubmed/32514025
http://dx.doi.org/10.1038/s41387-020-0121-x
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