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The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome
Coronavirus disease 2019 (COVID‐19), the disease resulting from infection by a novel coronavirus, SARS‐Cov2, has rapidly spread since November 2019 leading to a global pandemic. SARS‐Cov2 has infected over four million people and caused over 290,000 deaths worldwide. Although most cases are mild, a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280566/ https://www.ncbi.nlm.nih.gov/pubmed/32442317 http://dx.doi.org/10.1111/bph.15140 |
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author | Tamimi, Faleh Abusamak, Mohammad Akkanti, Bindu Chen, Zheng Yoo, Seung‐Hee Karmouty‐Quintana, Harry |
author_facet | Tamimi, Faleh Abusamak, Mohammad Akkanti, Bindu Chen, Zheng Yoo, Seung‐Hee Karmouty‐Quintana, Harry |
author_sort | Tamimi, Faleh |
collection | PubMed |
description | Coronavirus disease 2019 (COVID‐19), the disease resulting from infection by a novel coronavirus, SARS‐Cov2, has rapidly spread since November 2019 leading to a global pandemic. SARS‐Cov2 has infected over four million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of acute respiratory distress syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti‐inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS, and thus, chronotherapy may be used to effectively manage ARDS in COVID‐19 patients. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc |
format | Online Article Text |
id | pubmed-7280566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72805662020-06-09 The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome Tamimi, Faleh Abusamak, Mohammad Akkanti, Bindu Chen, Zheng Yoo, Seung‐Hee Karmouty‐Quintana, Harry Br J Pharmacol Themed Issue: Review Articles Coronavirus disease 2019 (COVID‐19), the disease resulting from infection by a novel coronavirus, SARS‐Cov2, has rapidly spread since November 2019 leading to a global pandemic. SARS‐Cov2 has infected over four million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of acute respiratory distress syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti‐inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS, and thus, chronotherapy may be used to effectively manage ARDS in COVID‐19 patients. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc John Wiley and Sons Inc. 2020-07-03 2020-11 /pmc/articles/PMC7280566/ /pubmed/32442317 http://dx.doi.org/10.1111/bph.15140 Text en © 2020 The British Pharmacological Society |
spellingShingle | Themed Issue: Review Articles Tamimi, Faleh Abusamak, Mohammad Akkanti, Bindu Chen, Zheng Yoo, Seung‐Hee Karmouty‐Quintana, Harry The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome |
title | The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome |
title_full | The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome |
title_fullStr | The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome |
title_full_unstemmed | The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome |
title_short | The case for chronotherapy in Covid‐19‐induced acute respiratory distress syndrome |
title_sort | case for chronotherapy in covid‐19‐induced acute respiratory distress syndrome |
topic | Themed Issue: Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280566/ https://www.ncbi.nlm.nih.gov/pubmed/32442317 http://dx.doi.org/10.1111/bph.15140 |
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