γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1...

Descripción completa

Detalles Bibliográficos
Autores principales: Willcox, Benjamin E., Mohammed, Fiyaz, Willcox, Carrie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280785/
https://www.ncbi.nlm.nih.gov/pubmed/32299647
http://dx.doi.org/10.1016/j.tibs.2020.03.012
_version_ 1783543785242755072
author Willcox, Benjamin E.
Mohammed, Fiyaz
Willcox, Carrie R.
author_facet Willcox, Benjamin E.
Mohammed, Fiyaz
Willcox, Carrie R.
author_sort Willcox, Benjamin E.
collection PubMed
description Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.
format Online
Article
Text
id pubmed-7280785
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Trends Journals
record_format MEDLINE/PubMed
spelling pubmed-72807852020-07-01 γδ TCR Recognition of MR1: Adapting to Life on the Flip Side Willcox, Benjamin E. Mohammed, Fiyaz Willcox, Carrie R. Trends Biochem Sci Article Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition. Elsevier Trends Journals 2020-07 /pmc/articles/PMC7280785/ /pubmed/32299647 http://dx.doi.org/10.1016/j.tibs.2020.03.012 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Willcox, Benjamin E.
Mohammed, Fiyaz
Willcox, Carrie R.
γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
title γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
title_full γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
title_fullStr γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
title_full_unstemmed γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
title_short γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
title_sort γδ tcr recognition of mr1: adapting to life on the flip side
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280785/
https://www.ncbi.nlm.nih.gov/pubmed/32299647
http://dx.doi.org/10.1016/j.tibs.2020.03.012
work_keys_str_mv AT willcoxbenjamine gdtcrrecognitionofmr1adaptingtolifeontheflipside
AT mohammedfiyaz gdtcrrecognitionofmr1adaptingtolifeontheflipside
AT willcoxcarrier gdtcrrecognitionofmr1adaptingtolifeontheflipside

Ejemplares similares