Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity

Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respectively. We previously showed that epitope and isotype interact to deliver optimal agonistic anti-CD40 mAbs. The impact of Fc engineering on antag...

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Detalles Bibliográficos
Autores principales: Yu, Xiaojie, Chan, H.T. Claude, Fisher, Hayden, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., English, Vikki, Verbeek, J. Sjef, White, Ann L., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280789/
https://www.ncbi.nlm.nih.gov/pubmed/32442402
http://dx.doi.org/10.1016/j.ccell.2020.04.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280789/
https://www.ncbi.nlm.nih.gov/pubmed/32442402
http://dx.doi.org/10.1016/j.ccell.2020.04.013

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