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Identification, Cloning and Heterologous Expression of the Gene Cluster Directing RES-701-3, -4 Lasso Peptides Biosynthesis from a Marine Streptomyces Strain

RES-701-3 and RES-701-4 are two class II lasso peptides originally identified in the fermentation broth of Streptomyces sp. RE-896, which have been described as selective endothelin type B receptor antagonists. These two lasso peptides only differ in the identity of the C-terminal residue (tryptopha...

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Detalles Bibliográficos
Autores principales: Oves-Costales, Daniel, Sánchez-Hidalgo, Marina, Martín, Jesús, Genilloud, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280977/
https://www.ncbi.nlm.nih.gov/pubmed/32370018
http://dx.doi.org/10.3390/md18050238