Cargando…

Cognitive Functions in Repeated Glioma Surgery

Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this a...

Descripción completa

Detalles Bibliográficos
Autores principales: Capo, Gabriele, Skrap, Miran, Guarracino, Ilaria, Isola, Miriam, Battistella, Claudio, Ius, Tamara, Tomasino, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281009/
https://www.ncbi.nlm.nih.gov/pubmed/32357421
http://dx.doi.org/10.3390/cancers12051077
_version_ 1783543831418896384
author Capo, Gabriele
Skrap, Miran
Guarracino, Ilaria
Isola, Miriam
Battistella, Claudio
Ius, Tamara
Tomasino, Barbara
author_facet Capo, Gabriele
Skrap, Miran
Guarracino, Ilaria
Isola, Miriam
Battistella, Claudio
Ius, Tamara
Tomasino, Barbara
author_sort Capo, Gabriele
collection PubMed
description Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this assumption is relatively ungrounded due to a lack of extensive neuropsychological testing. We retrospectively examined a series of 40 patients with recurrent glioma in eloquent areas of the left hemisphere, who all completed comprehensive pre- (T3) and post-surgical (T4) neuropsychological assessments after a second surgery (4-month follow up). The lesions were most frequent in the left insular cortex and the inferior frontal gyrus. Among this series, in 17 patients the cognitive outcomes were compared before the first surgery (T1), 4 months after the first surgery (T2), and at T3 and T4. There was no significant difference either in the number of patients scoring within the normal range between T3 and T4, or in their level of performance. Further addressing the T1–T4 evolution, there was no significant difference in the number of patients scoring within the normal range. As to their level of performance, the only significant change was in phonological fluency. This longitudinal follow-up study showed that repeated glioma surgery is possible without major damage to cognitive functions in the short-term period (4 months) after surgery.
format Online
Article
Text
id pubmed-7281009
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72810092020-06-15 Cognitive Functions in Repeated Glioma Surgery Capo, Gabriele Skrap, Miran Guarracino, Ilaria Isola, Miriam Battistella, Claudio Ius, Tamara Tomasino, Barbara Cancers (Basel) Article Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this assumption is relatively ungrounded due to a lack of extensive neuropsychological testing. We retrospectively examined a series of 40 patients with recurrent glioma in eloquent areas of the left hemisphere, who all completed comprehensive pre- (T3) and post-surgical (T4) neuropsychological assessments after a second surgery (4-month follow up). The lesions were most frequent in the left insular cortex and the inferior frontal gyrus. Among this series, in 17 patients the cognitive outcomes were compared before the first surgery (T1), 4 months after the first surgery (T2), and at T3 and T4. There was no significant difference either in the number of patients scoring within the normal range between T3 and T4, or in their level of performance. Further addressing the T1–T4 evolution, there was no significant difference in the number of patients scoring within the normal range. As to their level of performance, the only significant change was in phonological fluency. This longitudinal follow-up study showed that repeated glioma surgery is possible without major damage to cognitive functions in the short-term period (4 months) after surgery. MDPI 2020-04-26 /pmc/articles/PMC7281009/ /pubmed/32357421 http://dx.doi.org/10.3390/cancers12051077 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Capo, Gabriele
Skrap, Miran
Guarracino, Ilaria
Isola, Miriam
Battistella, Claudio
Ius, Tamara
Tomasino, Barbara
Cognitive Functions in Repeated Glioma Surgery
title Cognitive Functions in Repeated Glioma Surgery
title_full Cognitive Functions in Repeated Glioma Surgery
title_fullStr Cognitive Functions in Repeated Glioma Surgery
title_full_unstemmed Cognitive Functions in Repeated Glioma Surgery
title_short Cognitive Functions in Repeated Glioma Surgery
title_sort cognitive functions in repeated glioma surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281009/
https://www.ncbi.nlm.nih.gov/pubmed/32357421
http://dx.doi.org/10.3390/cancers12051077
work_keys_str_mv AT capogabriele cognitivefunctionsinrepeatedgliomasurgery
AT skrapmiran cognitivefunctionsinrepeatedgliomasurgery
AT guarracinoilaria cognitivefunctionsinrepeatedgliomasurgery
AT isolamiriam cognitivefunctionsinrepeatedgliomasurgery
AT battistellaclaudio cognitivefunctionsinrepeatedgliomasurgery
AT iustamara cognitivefunctionsinrepeatedgliomasurgery
AT tomasinobarbara cognitivefunctionsinrepeatedgliomasurgery