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Cognitive Functions in Repeated Glioma Surgery
Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281009/ https://www.ncbi.nlm.nih.gov/pubmed/32357421 http://dx.doi.org/10.3390/cancers12051077 |
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author | Capo, Gabriele Skrap, Miran Guarracino, Ilaria Isola, Miriam Battistella, Claudio Ius, Tamara Tomasino, Barbara |
author_facet | Capo, Gabriele Skrap, Miran Guarracino, Ilaria Isola, Miriam Battistella, Claudio Ius, Tamara Tomasino, Barbara |
author_sort | Capo, Gabriele |
collection | PubMed |
description | Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this assumption is relatively ungrounded due to a lack of extensive neuropsychological testing. We retrospectively examined a series of 40 patients with recurrent glioma in eloquent areas of the left hemisphere, who all completed comprehensive pre- (T3) and post-surgical (T4) neuropsychological assessments after a second surgery (4-month follow up). The lesions were most frequent in the left insular cortex and the inferior frontal gyrus. Among this series, in 17 patients the cognitive outcomes were compared before the first surgery (T1), 4 months after the first surgery (T2), and at T3 and T4. There was no significant difference either in the number of patients scoring within the normal range between T3 and T4, or in their level of performance. Further addressing the T1–T4 evolution, there was no significant difference in the number of patients scoring within the normal range. As to their level of performance, the only significant change was in phonological fluency. This longitudinal follow-up study showed that repeated glioma surgery is possible without major damage to cognitive functions in the short-term period (4 months) after surgery. |
format | Online Article Text |
id | pubmed-7281009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72810092020-06-15 Cognitive Functions in Repeated Glioma Surgery Capo, Gabriele Skrap, Miran Guarracino, Ilaria Isola, Miriam Battistella, Claudio Ius, Tamara Tomasino, Barbara Cancers (Basel) Article Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this assumption is relatively ungrounded due to a lack of extensive neuropsychological testing. We retrospectively examined a series of 40 patients with recurrent glioma in eloquent areas of the left hemisphere, who all completed comprehensive pre- (T3) and post-surgical (T4) neuropsychological assessments after a second surgery (4-month follow up). The lesions were most frequent in the left insular cortex and the inferior frontal gyrus. Among this series, in 17 patients the cognitive outcomes were compared before the first surgery (T1), 4 months after the first surgery (T2), and at T3 and T4. There was no significant difference either in the number of patients scoring within the normal range between T3 and T4, or in their level of performance. Further addressing the T1–T4 evolution, there was no significant difference in the number of patients scoring within the normal range. As to their level of performance, the only significant change was in phonological fluency. This longitudinal follow-up study showed that repeated glioma surgery is possible without major damage to cognitive functions in the short-term period (4 months) after surgery. MDPI 2020-04-26 /pmc/articles/PMC7281009/ /pubmed/32357421 http://dx.doi.org/10.3390/cancers12051077 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Capo, Gabriele Skrap, Miran Guarracino, Ilaria Isola, Miriam Battistella, Claudio Ius, Tamara Tomasino, Barbara Cognitive Functions in Repeated Glioma Surgery |
title | Cognitive Functions in Repeated Glioma Surgery |
title_full | Cognitive Functions in Repeated Glioma Surgery |
title_fullStr | Cognitive Functions in Repeated Glioma Surgery |
title_full_unstemmed | Cognitive Functions in Repeated Glioma Surgery |
title_short | Cognitive Functions in Repeated Glioma Surgery |
title_sort | cognitive functions in repeated glioma surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281009/ https://www.ncbi.nlm.nih.gov/pubmed/32357421 http://dx.doi.org/10.3390/cancers12051077 |
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