Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.

Four new brominated tyrosine metabolites, aplyzanzines C–F (1–4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Ver...

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Autores principales: Tintillier, Florent, Moriou, Céline, Petek, Sylvain, Fauchon, Marilyne, Hellio, Claire, Saulnier, Denis, Ekins, Merrick, Hooper, John N. A., Al-Mourabit, Ali, Debitus, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281015/
https://www.ncbi.nlm.nih.gov/pubmed/32455754
http://dx.doi.org/10.3390/md18050272
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author Tintillier, Florent
Moriou, Céline
Petek, Sylvain
Fauchon, Marilyne
Hellio, Claire
Saulnier, Denis
Ekins, Merrick
Hooper, John N. A.
Al-Mourabit, Ali
Debitus, Cécile
author_facet Tintillier, Florent
Moriou, Céline
Petek, Sylvain
Fauchon, Marilyne
Hellio, Claire
Saulnier, Denis
Ekins, Merrick
Hooper, John N. A.
Al-Mourabit, Ali
Debitus, Cécile
author_sort Tintillier, Florent
collection PubMed
description Four new brominated tyrosine metabolites, aplyzanzines C–F (1–4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time.
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spelling pubmed-72810152020-06-15 Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp. Tintillier, Florent Moriou, Céline Petek, Sylvain Fauchon, Marilyne Hellio, Claire Saulnier, Denis Ekins, Merrick Hooper, John N. A. Al-Mourabit, Ali Debitus, Cécile Mar Drugs Article Four new brominated tyrosine metabolites, aplyzanzines C–F (1–4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time. MDPI 2020-05-21 /pmc/articles/PMC7281015/ /pubmed/32455754 http://dx.doi.org/10.3390/md18050272 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tintillier, Florent
Moriou, Céline
Petek, Sylvain
Fauchon, Marilyne
Hellio, Claire
Saulnier, Denis
Ekins, Merrick
Hooper, John N. A.
Al-Mourabit, Ali
Debitus, Cécile
Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
title Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
title_full Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
title_fullStr Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
title_full_unstemmed Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
title_short Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
title_sort quorum sensing inhibitory and antifouling activities of new bromotyrosine metabolites from the polynesian sponge pseudoceratina n. sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281015/
https://www.ncbi.nlm.nih.gov/pubmed/32455754
http://dx.doi.org/10.3390/md18050272
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