Cargando…

Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer

The phenomenon of high sugar consumption by tumor cells is known as Warburg effect. It results from a high glycolysis rate, used by tumors as preferred metabolic pathway even in aerobic conditions. Targeting the Warburg effect to specifically deliver sugar conjugated cytotoxic compounds into tumor c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dyshlovoy, Sergey A., Pelageev, Dmitry N., Hauschild, Jessica, Sabutskii, Yurii E., Khmelevskaya, Ekaterina A., Krisp, Christoph, Kaune, Moritz, Venz, Simone, Borisova, Ksenia L., Busenbender, Tobias, Denisenko, Vladimir A., Schlüter, Hartmut, Bokemeyer, Carsten, Graefen, Markus, Polonik, Sergey G., Anufriev, Victor Ph., von Amsberg, Gunhild
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281150/ https://www.ncbi.nlm.nih.gov/pubmed/32403427 http://dx.doi.org/10.3390/md18050251

Ejemplares similares

Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones
por: Dyshlovoy, Sergey A., et al.
Publicado: (2019)

Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2021)

New Marine Fungal Deoxy-14,15-Dehydroisoaustamide Resensitizes Prostate Cancer Cells to Enzalutamide
por: Dyshlovoy, Sergey A., et al.
Publicado: (2023)

Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

Cytotoxic N-Methylpretrichodermamide B Reveals Anticancer Activity and Inhibits P-Glycoprotein in Drug-Resistant Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2022)

Immunotherapy in Advanced Prostate Cancer—Light at the End of the Tunnel?
por: von Amsberg, Gunhild, et al.
Publicado: (2022)

Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-ActivityAnalysis of Substituted 5,8-Dihydroxy-1,4-naphthoquinones and Their O- and S-Glycoside Derivatives Tested against Neuro-2a Cancer Cells
por: Polonik, Sergey, et al.
Publicado: (2020)

Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

Salvage Chemotherapy with Cisplatin, Ifosfamide, and Paclitaxel in Aggressive Variant of Metastatic Castration-Resistant Prostate Cancer
por: von Amsberg, Gunhild, et al.
Publicado: (2022)

Study of Structure–Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents
por: Zhidkov, Maxim E., et al.
Publicado: (2022)

Neuroprotective Effect of 1,4-Naphthoquinones in an In Vitro Model of Paraquat and 6-OHDA-Induced Neurotoxicity
por: Menchinskaya, Ekaterina, et al.
Publicado: (2021)

New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein
por: Dyshlovoy, Sergey A., et al.
Publicado: (2022)

Aaptamines from the Marine Sponge Aaptos sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2014)

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
por: Dyshlovoy, Sergey A., et al.
Publicado: (2015)

Dimeric (Poly)Hydroxynaphthazarins, Metabolites of Echinoderms and Lichens: The History of the Synthesis and Structure Elucidation
por: Pelageev, Dmitry N., et al.
Publicado: (2023)

New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
por: Tabakmakher, Kseniya M., et al.
Publicado: (2019)

Synthesis and anticancer activity of the derivatives of marine compound rhizochalin in castration resistant prostate cancer
por: Dyshlovoy, Sergey A., et al.
Publicado: (2018)

Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones
por: Sabutski, Yuri E., et al.
Publicado: (2020)

New Guanidine Alkaloids Batzelladines O and P from the Marine Sponge Monanchora pulchra Induce Apoptosis and Autophagy in Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2022)

New Bioactive β-Resorcylic Acid Derivatives from the Alga-Derived Fungus Penicillium antarcticum KMM 4685
por: Leshchenko, Elena V., et al.
Publicado: (2023)

The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2017)

Gracilosulfates A–G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis
por: Shubina, Larisa K., et al.
Publicado: (2020)

Sea Anemone Heteractis crispa Actinoporin Demonstrates In Vitro Anticancer Activities and Prevents HT-29 Colorectal Cancer Cell Migration
por: Kvetkina, Aleksandra, et al.
Publicado: (2020)

The Inhibitory Activity of Luzonicosides from the Starfish Echinaster luzonicus against Human Melanoma Cells
por: Malyarenko, Olesya S., et al.
Publicado: (2017)

Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro
por: Dyshlovoy, Sergey A., et al.
Publicado: (2016)

Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues
por: Zhidkov, Maxim E., et al.
Publicado: (2019)

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells
por: Kozlovskiy, Sergei A., et al.
Publicado: (2023)

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer
por: Dyshlovoy, Sergey A., et al.
Publicado: (2016)

Zosteropenillines: Polyketides from the Marine-Derived Fungus Penicillium thomii
por: Afiyatullov, Shamil Sh., et al.
Publicado: (2017)

Tetracyclic 1,4-Naphthoquinone Thioglucoside Conjugate U-556 Blocks the Purinergic P2X7 Receptor in Macrophages and Exhibits Anti-Inflammatory Activity In Vivo
por: Kozlovskiy, Sergei, et al.
Publicado: (2023)

Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death
por: Spirin, Pavel, et al.
Publicado: (2021)

Piltunines A–F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
por: Afiyatullov, Shamil Sh., et al.
Publicado: (2019)

Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672
por: Yurchenko, Anton N., et al.
Publicado: (2016)

A New Mild Method for Synthesis of Marine Alkaloid Fascaplysin and Its Therapeutically Promising Derivatives
por: Tryapkin, Oleg A., et al.
Publicado: (2023)

Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.
por: Kapustina, Irina I., et al.
Publicado: (2020)

New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
por: Zhuravleva, Olesya I., et al.
Publicado: (2021)

New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus Asteromyces cruciatus KMM 4696
por: Zhuravleva, Olesya I., et al.
Publicado: (2022)

1-O-Alkylglycerol Ethers from the Marine Sponge Guitarra abbotti and Their Cytotoxic Activity
por: Dyshlovoy, Sergey A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_469fkot76heu1kvoqg2122fnfs