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Systems Biology ARDS Research with a Focus on Metabolomics
Acute respiratory distress syndrome (ARDS) is a clinical syndrome that inflicts a considerably heavy toll in terms of morbidity and mortality. While there are multitudes of conditions that can lead to ARDS, the vast majority of ARDS cases are caused by a relatively small number of diseases, especial...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281154/ https://www.ncbi.nlm.nih.gov/pubmed/32438561 http://dx.doi.org/10.3390/metabo10050207 |
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author | Metwaly, Sayed M. Winston, Brent W. |
author_facet | Metwaly, Sayed M. Winston, Brent W. |
author_sort | Metwaly, Sayed M. |
collection | PubMed |
description | Acute respiratory distress syndrome (ARDS) is a clinical syndrome that inflicts a considerably heavy toll in terms of morbidity and mortality. While there are multitudes of conditions that can lead to ARDS, the vast majority of ARDS cases are caused by a relatively small number of diseases, especially sepsis and pneumonia. Currently, there is no clinically agreed upon reliable diagnostic test for ARDS, and the detection or diagnosis of ARDS is based on a constellation of laboratory and radiological tests in the absence of evidence of left ventricular dysfunction, as specified by the Berlin definition of ARDS. Virtually all the ARDS biomarkers to date have been proven to be of very limited clinical utility. Given the heterogeneity of ARDS due to the wide variation in etiology, clinical and molecular manifestations, there is a current scientific consensus agreement that ARDS is not just a single entity but rather a spectrum of conditions that need further study for proper classification, the identification of reliable biomarkers and the adequate institution of therapeutic targets. This scoping review aims to elucidate ARDS omics research, focusing on metabolomics and how metabolomics can boost the study of ARDS biomarkers and help to facilitate the identification of ARDS subpopulations. |
format | Online Article Text |
id | pubmed-7281154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72811542020-06-15 Systems Biology ARDS Research with a Focus on Metabolomics Metwaly, Sayed M. Winston, Brent W. Metabolites Review Acute respiratory distress syndrome (ARDS) is a clinical syndrome that inflicts a considerably heavy toll in terms of morbidity and mortality. While there are multitudes of conditions that can lead to ARDS, the vast majority of ARDS cases are caused by a relatively small number of diseases, especially sepsis and pneumonia. Currently, there is no clinically agreed upon reliable diagnostic test for ARDS, and the detection or diagnosis of ARDS is based on a constellation of laboratory and radiological tests in the absence of evidence of left ventricular dysfunction, as specified by the Berlin definition of ARDS. Virtually all the ARDS biomarkers to date have been proven to be of very limited clinical utility. Given the heterogeneity of ARDS due to the wide variation in etiology, clinical and molecular manifestations, there is a current scientific consensus agreement that ARDS is not just a single entity but rather a spectrum of conditions that need further study for proper classification, the identification of reliable biomarkers and the adequate institution of therapeutic targets. This scoping review aims to elucidate ARDS omics research, focusing on metabolomics and how metabolomics can boost the study of ARDS biomarkers and help to facilitate the identification of ARDS subpopulations. MDPI 2020-05-19 /pmc/articles/PMC7281154/ /pubmed/32438561 http://dx.doi.org/10.3390/metabo10050207 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Metwaly, Sayed M. Winston, Brent W. Systems Biology ARDS Research with a Focus on Metabolomics |
title | Systems Biology ARDS Research with a Focus on Metabolomics |
title_full | Systems Biology ARDS Research with a Focus on Metabolomics |
title_fullStr | Systems Biology ARDS Research with a Focus on Metabolomics |
title_full_unstemmed | Systems Biology ARDS Research with a Focus on Metabolomics |
title_short | Systems Biology ARDS Research with a Focus on Metabolomics |
title_sort | systems biology ards research with a focus on metabolomics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281154/ https://www.ncbi.nlm.nih.gov/pubmed/32438561 http://dx.doi.org/10.3390/metabo10050207 |
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