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Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy

Opportunities for surgical treatment in metastatic melanoma patients have re-emerged due to the development of novel systemic therapeutics over the past decade. The aim of this study is to present data on outcomes of surgery in patients with unresectable stage IIIC and IV melanoma, who have previous...

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Autores principales: Blankenstein, Stephanie A., Aarts, Maureen J. B., van den Berkmortel, Franchette W. P. J., Boers-Sonderen, Marye J., van den Eertwegh, Alfons J. M., Franken, Margreet G., de Groot, Jan Willem B., Haanen, John B. A. G., Hospers, Geke A. P., Kapiteijn, Ellen, Piersma, Djura, van Rijn, Rozemarijn S., Suijkerbuijk, Karijn P. M., ten Tije, Albert J., van der Veldt, Astrid A. M., Vreugdenhil, Gerard, Wouters, Michel W. J. M., van Akkooi, Alexander C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281176/
https://www.ncbi.nlm.nih.gov/pubmed/32392717
http://dx.doi.org/10.3390/cancers12051176
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author Blankenstein, Stephanie A.
Aarts, Maureen J. B.
van den Berkmortel, Franchette W. P. J.
Boers-Sonderen, Marye J.
van den Eertwegh, Alfons J. M.
Franken, Margreet G.
de Groot, Jan Willem B.
Haanen, John B. A. G.
Hospers, Geke A. P.
Kapiteijn, Ellen
Piersma, Djura
van Rijn, Rozemarijn S.
Suijkerbuijk, Karijn P. M.
ten Tije, Albert J.
van der Veldt, Astrid A. M.
Vreugdenhil, Gerard
Wouters, Michel W. J. M.
van Akkooi, Alexander C. J.
author_facet Blankenstein, Stephanie A.
Aarts, Maureen J. B.
van den Berkmortel, Franchette W. P. J.
Boers-Sonderen, Marye J.
van den Eertwegh, Alfons J. M.
Franken, Margreet G.
de Groot, Jan Willem B.
Haanen, John B. A. G.
Hospers, Geke A. P.
Kapiteijn, Ellen
Piersma, Djura
van Rijn, Rozemarijn S.
Suijkerbuijk, Karijn P. M.
ten Tije, Albert J.
van der Veldt, Astrid A. M.
Vreugdenhil, Gerard
Wouters, Michel W. J. M.
van Akkooi, Alexander C. J.
author_sort Blankenstein, Stephanie A.
collection PubMed
description Opportunities for surgical treatment in metastatic melanoma patients have re-emerged due to the development of novel systemic therapeutics over the past decade. The aim of this study is to present data on outcomes of surgery in patients with unresectable stage IIIC and IV melanoma, who have previously been treated with immunotherapy or targeted therapy. Data was extracted from the Dutch Melanoma Treatment Registry (DMTR) on 154 patients obtaining disease control to systemic therapy and undergoing subsequent surgery. Disease control was defined as a complete response (CR), which was seen in 3.2% of patients; a partial response (PR), seen in 46.1% of patients; or stable disease (SD), seen in 44.2% of patients. At a median follow-up of 10.0 months (interquartile range 4–22) after surgery, the median overall survival (OS) had not been reached in our cohort and median progression-free survival (PFS) was 9.0 months (95% CI 6.3–11.7). A CR or PR at first follow-up after surgery was associated with both a better OS and PFS compared to stable or progressive disease (p < 0.001). We conclude that selected patients can benefit from surgery after achieving disease control with systemic therapy.
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spelling pubmed-72811762020-06-15 Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy Blankenstein, Stephanie A. Aarts, Maureen J. B. van den Berkmortel, Franchette W. P. J. Boers-Sonderen, Marye J. van den Eertwegh, Alfons J. M. Franken, Margreet G. de Groot, Jan Willem B. Haanen, John B. A. G. Hospers, Geke A. P. Kapiteijn, Ellen Piersma, Djura van Rijn, Rozemarijn S. Suijkerbuijk, Karijn P. M. ten Tije, Albert J. van der Veldt, Astrid A. M. Vreugdenhil, Gerard Wouters, Michel W. J. M. van Akkooi, Alexander C. J. Cancers (Basel) Article Opportunities for surgical treatment in metastatic melanoma patients have re-emerged due to the development of novel systemic therapeutics over the past decade. The aim of this study is to present data on outcomes of surgery in patients with unresectable stage IIIC and IV melanoma, who have previously been treated with immunotherapy or targeted therapy. Data was extracted from the Dutch Melanoma Treatment Registry (DMTR) on 154 patients obtaining disease control to systemic therapy and undergoing subsequent surgery. Disease control was defined as a complete response (CR), which was seen in 3.2% of patients; a partial response (PR), seen in 46.1% of patients; or stable disease (SD), seen in 44.2% of patients. At a median follow-up of 10.0 months (interquartile range 4–22) after surgery, the median overall survival (OS) had not been reached in our cohort and median progression-free survival (PFS) was 9.0 months (95% CI 6.3–11.7). A CR or PR at first follow-up after surgery was associated with both a better OS and PFS compared to stable or progressive disease (p < 0.001). We conclude that selected patients can benefit from surgery after achieving disease control with systemic therapy. MDPI 2020-05-07 /pmc/articles/PMC7281176/ /pubmed/32392717 http://dx.doi.org/10.3390/cancers12051176 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blankenstein, Stephanie A.
Aarts, Maureen J. B.
van den Berkmortel, Franchette W. P. J.
Boers-Sonderen, Marye J.
van den Eertwegh, Alfons J. M.
Franken, Margreet G.
de Groot, Jan Willem B.
Haanen, John B. A. G.
Hospers, Geke A. P.
Kapiteijn, Ellen
Piersma, Djura
van Rijn, Rozemarijn S.
Suijkerbuijk, Karijn P. M.
ten Tije, Albert J.
van der Veldt, Astrid A. M.
Vreugdenhil, Gerard
Wouters, Michel W. J. M.
van Akkooi, Alexander C. J.
Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy
title Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy
title_full Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy
title_fullStr Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy
title_full_unstemmed Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy
title_short Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy
title_sort surgery for unresectable stage iiic and iv melanoma in the era of new systemic therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281176/
https://www.ncbi.nlm.nih.gov/pubmed/32392717
http://dx.doi.org/10.3390/cancers12051176
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