Cargando…

Pathogenomics and Management of Fusarium Diseases in Plants

There is an urgency to supplant the heavy reliance on chemical control of Fusarium diseases in different economically important, staple food crops due to development of resistance in the pathogen population, the high cost of production to the risk-averse grower, and the concomitant environmental imp...

Descripción completa

Detalles Bibliográficos
Autor principal: Rampersad, Sephra N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281180/
https://www.ncbi.nlm.nih.gov/pubmed/32369942
http://dx.doi.org/10.3390/pathogens9050340
_version_ 1783543862553214976
author Rampersad, Sephra N.
author_facet Rampersad, Sephra N.
author_sort Rampersad, Sephra N.
collection PubMed
description There is an urgency to supplant the heavy reliance on chemical control of Fusarium diseases in different economically important, staple food crops due to development of resistance in the pathogen population, the high cost of production to the risk-averse grower, and the concomitant environmental impacts. Pathogenomics has enabled (i) the creation of genetic inventories which identify those putative genes, regulators, and effectors that are associated with virulence, pathogenicity, and primary and secondary metabolism; (ii) comparison of such genes among related pathogens; (iii) identification of potential genetic targets for chemical control; and (iv) better characterization of the complex dynamics of host–microbe interactions that lead to disease. This type of genomic data serves to inform host-induced gene silencing (HIGS) technology for targeted disruption of transcription of select genes for the control of Fusarium diseases. This review discusses the various repositories and browser access points for comparison of genomic data, the strategies for identification and selection of pathogenicity- and virulence-associated genes and effectors in different Fusarium species, HIGS and successful Fusarium disease control trials with a consideration of loss of RNAi, off-target effects, and future challenges in applying HIGS for management of Fusarium diseases.
format Online
Article
Text
id pubmed-7281180
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72811802020-06-15 Pathogenomics and Management of Fusarium Diseases in Plants Rampersad, Sephra N. Pathogens Review There is an urgency to supplant the heavy reliance on chemical control of Fusarium diseases in different economically important, staple food crops due to development of resistance in the pathogen population, the high cost of production to the risk-averse grower, and the concomitant environmental impacts. Pathogenomics has enabled (i) the creation of genetic inventories which identify those putative genes, regulators, and effectors that are associated with virulence, pathogenicity, and primary and secondary metabolism; (ii) comparison of such genes among related pathogens; (iii) identification of potential genetic targets for chemical control; and (iv) better characterization of the complex dynamics of host–microbe interactions that lead to disease. This type of genomic data serves to inform host-induced gene silencing (HIGS) technology for targeted disruption of transcription of select genes for the control of Fusarium diseases. This review discusses the various repositories and browser access points for comparison of genomic data, the strategies for identification and selection of pathogenicity- and virulence-associated genes and effectors in different Fusarium species, HIGS and successful Fusarium disease control trials with a consideration of loss of RNAi, off-target effects, and future challenges in applying HIGS for management of Fusarium diseases. MDPI 2020-05-01 /pmc/articles/PMC7281180/ /pubmed/32369942 http://dx.doi.org/10.3390/pathogens9050340 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rampersad, Sephra N.
Pathogenomics and Management of Fusarium Diseases in Plants
title Pathogenomics and Management of Fusarium Diseases in Plants
title_full Pathogenomics and Management of Fusarium Diseases in Plants
title_fullStr Pathogenomics and Management of Fusarium Diseases in Plants
title_full_unstemmed Pathogenomics and Management of Fusarium Diseases in Plants
title_short Pathogenomics and Management of Fusarium Diseases in Plants
title_sort pathogenomics and management of fusarium diseases in plants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281180/
https://www.ncbi.nlm.nih.gov/pubmed/32369942
http://dx.doi.org/10.3390/pathogens9050340
work_keys_str_mv AT rampersadsephran pathogenomicsandmanagementoffusariumdiseasesinplants