Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on t...

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Autores principales: Mabrouk, Nesrine, Ghione, Silvia, Laurens, Véronique, Plenchette, Stéphanie, Bettaieb, Ali, Paul, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281185/
https://www.ncbi.nlm.nih.gov/pubmed/32370259
http://dx.doi.org/10.3390/cancers12051145
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author Mabrouk, Nesrine
Ghione, Silvia
Laurens, Véronique
Plenchette, Stéphanie
Bettaieb, Ali
Paul, Catherine
author_facet Mabrouk, Nesrine
Ghione, Silvia
Laurens, Véronique
Plenchette, Stéphanie
Bettaieb, Ali
Paul, Catherine
author_sort Mabrouk, Nesrine
collection PubMed
description Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.
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spelling pubmed-72811852020-06-15 Senescence and Cancer: Role of Nitric Oxide (NO) in SASP Mabrouk, Nesrine Ghione, Silvia Laurens, Véronique Plenchette, Stéphanie Bettaieb, Ali Paul, Catherine Cancers (Basel) Review Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment. MDPI 2020-05-02 /pmc/articles/PMC7281185/ /pubmed/32370259 http://dx.doi.org/10.3390/cancers12051145 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mabrouk, Nesrine
Ghione, Silvia
Laurens, Véronique
Plenchette, Stéphanie
Bettaieb, Ali
Paul, Catherine
Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
title Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
title_full Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
title_fullStr Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
title_full_unstemmed Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
title_short Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
title_sort senescence and cancer: role of nitric oxide (no) in sasp
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281185/
https://www.ncbi.nlm.nih.gov/pubmed/32370259
http://dx.doi.org/10.3390/cancers12051145
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