Cargando…

Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles

The tumor organoid (tumoroid) model in three-dimensional (3D) culture systems has been developed to reflect more closely the in vivo tumors than 2D-cultured tumor cells. Notably, extracellular vesicles (EVs) are efficiently collectible from the culture supernatant of gel-free tumoroids. Matrix metal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taha, Eman A., Sogawa, Chiharu, Okusha, Yuka, Kawai, Hotaka, Oo, May Wathone, Elseoudi, Abdellatif, Lu, Yanyin, Nagatsuka, Hitoshi, Kubota, Satoshi, Satoh, Ayano, Okamoto, Kuniaki, Eguchi, Takanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281240/ https://www.ncbi.nlm.nih.gov/pubmed/32429403 http://dx.doi.org/10.3390/cancers12051260

Ejemplares similares

Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer
por: Ono, Kisho, et al.
Publicado: (2020)

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3
por: Sogawa, Chiharu, et al.
Publicado: (2020)

Cancer-Associated Stromal Cells Promote the Contribution of MMP2-Positive Bone Marrow-Derived Cells to Oral Squamous Cell Carcinoma Invasion
por: Oo, May Wathone, et al.
Publicado: (2021)

Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer
por: Sogawa, Chiharu, et al.
Publicado: (2021)

Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer
por: Yoshida, Saori, et al.
Publicado: (2019)

Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
por: Kawai, Hotaka, et al.
Publicado: (2021)

Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells
por: Namba, Yuri, et al.
Publicado: (2018)

Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors
por: Okusha, Yuka, et al.
Publicado: (2020)

Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells
por: Eguchi, Takanori, et al.
Publicado: (2020)

A Pilot Study of Seamless Regeneration of Bone and Cartilage in Knee Joint Regeneration Using Honeycomb TCP
por: Takabatake, Kiyofumi, et al.
Publicado: (2021)

Crosstalk between cancer and different cancer stroma subtypes promotes the infiltration of tumor-associated macrophages into the tumor microenvironment of oral squamous cell carcinoma
por: Shan, Qiusheng, et al.
Publicado: (2022)

Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment
por: Oo, May Wathone, et al.
Publicado: (2022)

Exosome-Based Molecular Transfer Activity of Macrophage-Like Cells Involves Viability of Oral Carcinoma Cells: Size Exclusion Chromatography and Concentration Filter Method
por: Lu, Yanyin, et al.
Publicado: (2021)

Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma
por: Takabatake, Kiyofumi, et al.
Publicado: (2020)

Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma
por: Shan, Qiusheng, et al.
Publicado: (2021)

Significance of cancer stroma for bone destruction in oral squamous cell carcinoma using different cancer stroma subtypes
por: Shan, Qiusheng, et al.
Publicado: (2022)

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment
por: Eguchi, Takanori, et al.
Publicado: (2018)

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer
por: Okusha, Yuka, et al.
Publicado: (2020)

The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors
por: Tran, Manh Tien, et al.
Publicado: (2020)

Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line-derived xenograft model
por: Shan, Qiusheng, et al.
Publicado: (2022)

The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma
por: Takabatake, Kiyofumi, et al.
Publicado: (2019)

Differentiation and roles of bone marrow-derived cells on the tumor microenvironment of oral squamous cell carcinoma
por: Anqi, Chang, et al.
Publicado: (2019)

Enzyme‐Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells
por: Kawai, Hotaka, et al.
Publicado: (2023)

Dynamic contrast-enhanced MRI as a predictor of programmed death ligand-1 expression in patients with oral squamous cell carcinoma
por: Tekiki, Nouha, et al.
Publicado: (2021)

SOD3 Expression in Tumor Stroma Provides the Tumor Vessel Maturity in Oral Squamous Cell Carcinoma
por: Oo, May Wathone, et al.
Publicado: (2022)

Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma
por: Hasegawa, Kazuaki, et al.
Publicado: (2018)

Immunohistochemistry of YAP and dNp63 and survival analysis of patients bearing precancerous lesion and oral squamous cell carcinoma
por: Ono, Sawako, et al.
Publicado: (2019)

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Miyake, Saki, et al.
Publicado: (2019)

Extracellular Vesicles: New Classification and Tumor Immunosuppression
por: Sheta, Mona, et al.
Publicado: (2023)

Generation and validation of APOE knockout human iPSC-derived cerebral organoids
por: Martens, Yuka A., et al.
Publicado: (2021)

Rapid establishment of human colonic organoid knockout lines
por: Gu, Wei, et al.
Publicado: (2022)

Weakening HIV
por: Bashyam, Hema
Publicado: (2008)

Weakened defences
por: Whyte, Chelsea
Publicado: (2020)

Feasible Advantage of Bioactive/Bioresorbable Devices Made of Forged Composites of Hydroxyapatite Particles and Poly-L-lactide in Alveolar Bone Augmentation: A Preliminary Study
por: Sukegawa, Shintaro, et al.
Publicado: (2019)

Notch Signaling Affects Oral Neoplasm Cell Differentiation and Acquisition of Tumor-Specific Characteristics
por: Nakano, Keisuke, et al.
Publicado: (2019)

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology
por: Sukegawa, Shintaro, et al.
Publicado: (2020)

Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide
por: Sukegawa, Shintaro, et al.
Publicado: (2019)

Biological Effects of Bioresorbable Materials in Alveolar Ridge Augmentation: Comparison of Early and Slow Resorbing Osteosynthesis Materials
por: Kawai, Hotaka, et al.
Publicado: (2021)

Rubber tail illusion is weakened in Ca(2+)-dependent activator protein for secretion 2 (Caps2)-knockout mice
por: Wada, Makoto, et al.
Publicado: (2019)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation
por: Shintani, Tomohiro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f391bvj9h680026eg3rdhrurse