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Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models

Low-dose irradiation (LDI) has recently been shown to have various beneficial effects on human health, such as on cellular metabolic activities, DNA repair, antioxidant activity, homeostasis potency, and immune activation. Although studies on the immunogenic effects of LDI are rapidly accumulating,...

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Autores principales: Song, Kyung-Hee, Jung, Seung-Youn, Park, Jeong-In, Ahn, Jiyeon, Park, Jong-Kuk, Hwang, Sang-Gu, Kim, Eun-Ho, Nam, Seon Young, Park, Seungwoo, Ha, Hunjoo, Song, Jie-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281283/
https://www.ncbi.nlm.nih.gov/pubmed/32365904
http://dx.doi.org/10.3390/cancers12051126
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author Song, Kyung-Hee
Jung, Seung-Youn
Park, Jeong-In
Ahn, Jiyeon
Park, Jong-Kuk
Hwang, Sang-Gu
Kim, Eun-Ho
Nam, Seon Young
Park, Seungwoo
Ha, Hunjoo
Song, Jie-Young
author_facet Song, Kyung-Hee
Jung, Seung-Youn
Park, Jeong-In
Ahn, Jiyeon
Park, Jong-Kuk
Hwang, Sang-Gu
Kim, Eun-Ho
Nam, Seon Young
Park, Seungwoo
Ha, Hunjoo
Song, Jie-Young
author_sort Song, Kyung-Hee
collection PubMed
description Low-dose irradiation (LDI) has recently been shown to have various beneficial effects on human health, such as on cellular metabolic activities, DNA repair, antioxidant activity, homeostasis potency, and immune activation. Although studies on the immunogenic effects of LDI are rapidly accumulating, clinical trials for cancer treatment are considered premature owing to the lack of available preclinical results and protocols. Here, we aim to investigate anti-tumor and anti-metastatic effects of whole-body LDI in several tumor-bearing mouse models. Mice were exposed to single or fractionated whole-body LDI prior to tumor transplantation, and tumor growth and metastatic potential were determined, along with analysis of immune cell populations and expression of epithelial–mesenchymal transition (EMT) markers. Whole-body fractionated-LDI decreased tumor development and lung metastasis not only by infiltration of CD4(+), CD8(+) T-cells, and dendritic cells (DCs) but also by attenuating EMT. Moreover, a combination of whole-body LDI with localized high-dose radiation therapy reduced the non-irradiated abscopal tumor growth and increased infiltration of effector T cells and DCs. Therefore, whole-body LDI in combination with high-dose radiation therapy could be a potential therapeutic strategy for treating cancer.
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spelling pubmed-72812832020-06-19 Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models Song, Kyung-Hee Jung, Seung-Youn Park, Jeong-In Ahn, Jiyeon Park, Jong-Kuk Hwang, Sang-Gu Kim, Eun-Ho Nam, Seon Young Park, Seungwoo Ha, Hunjoo Song, Jie-Young Cancers (Basel) Article Low-dose irradiation (LDI) has recently been shown to have various beneficial effects on human health, such as on cellular metabolic activities, DNA repair, antioxidant activity, homeostasis potency, and immune activation. Although studies on the immunogenic effects of LDI are rapidly accumulating, clinical trials for cancer treatment are considered premature owing to the lack of available preclinical results and protocols. Here, we aim to investigate anti-tumor and anti-metastatic effects of whole-body LDI in several tumor-bearing mouse models. Mice were exposed to single or fractionated whole-body LDI prior to tumor transplantation, and tumor growth and metastatic potential were determined, along with analysis of immune cell populations and expression of epithelial–mesenchymal transition (EMT) markers. Whole-body fractionated-LDI decreased tumor development and lung metastasis not only by infiltration of CD4(+), CD8(+) T-cells, and dendritic cells (DCs) but also by attenuating EMT. Moreover, a combination of whole-body LDI with localized high-dose radiation therapy reduced the non-irradiated abscopal tumor growth and increased infiltration of effector T cells and DCs. Therefore, whole-body LDI in combination with high-dose radiation therapy could be a potential therapeutic strategy for treating cancer. MDPI 2020-04-30 /pmc/articles/PMC7281283/ /pubmed/32365904 http://dx.doi.org/10.3390/cancers12051126 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Kyung-Hee
Jung, Seung-Youn
Park, Jeong-In
Ahn, Jiyeon
Park, Jong-Kuk
Hwang, Sang-Gu
Kim, Eun-Ho
Nam, Seon Young
Park, Seungwoo
Ha, Hunjoo
Song, Jie-Young
Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
title Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
title_full Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
title_fullStr Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
title_full_unstemmed Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
title_short Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models
title_sort evaluation of anti-tumor effects of whole-body low-dose irradiation in metastatic mouse models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281283/
https://www.ncbi.nlm.nih.gov/pubmed/32365904
http://dx.doi.org/10.3390/cancers12051126
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