An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

Using a mini-library of 1062 lentiviral shRNAs targeting 40 nuclear hormone receptors and 70 of their co-regulators, we searched for potential therapeutic targets that would be important during in vivo tumor growth using a parallel in vitro and in vivo shRNA screening strategy in the non-small cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Hight, Suzie K., Mootz, Allison, Kollipara, Rahul K., McMillan, Elizabeth, Yenerall, Paul, Otaki, Yoichi, Li, Long-Shan, Avila, Kimberley, Peyton, Michael, Rodriguez-Canales, Jaime, Mino, Barbara, Villalobos, Pamela, Girard, Luc, Dospoy, Patrick, Larsen, Jill, White, Michael A., Heymach, John V., Wistuba, Ignacio I., Kittler, Ralf, Minna, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281309/
https://www.ncbi.nlm.nih.gov/pubmed/32512502
http://dx.doi.org/10.1016/j.neo.2020.04.005

Ejemplares similares

Ejemplares similares