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author Soriano-Arandes, Antoni
Frick, Marie Antoinette
García López-Hortelano, Milagros
Sulleiro, Elena
Rodó, Carlota
Sánchez-Seco, María Paz
Cabrera-Lafuente, Marta
Suy, Anna
De la Calle, María
Santos, Mar
Antolin, Eugenia
Viñuela, María del Carmen
Espiau, María
Salazar, Ainara
Guarch-Ibáñez, Borja
Vázquez, Ana
Navarro-Morón, Juan
Ramos-Amador, José-Tomás
Martin-Nalda, Andrea
Dueñas, Eva
Blázquez-Gamero, Daniel
Reques-Cosme, Resurrección
Olabarrieta, Iciar
Prieto, Luis
De Ory, Fernando
Thorne, Claire
Byrne, Thomas
Ades, Anthony E.
Ruiz-Burga, Elisa
Giaquinto, Carlo
Mellado-Peña, María José
García-Alix, Alfredo
Carreras, Elena
Soler-Palacín, Pere
author_facet Soriano-Arandes, Antoni
Frick, Marie Antoinette
García López-Hortelano, Milagros
Sulleiro, Elena
Rodó, Carlota
Sánchez-Seco, María Paz
Cabrera-Lafuente, Marta
Suy, Anna
De la Calle, María
Santos, Mar
Antolin, Eugenia
Viñuela, María del Carmen
Espiau, María
Salazar, Ainara
Guarch-Ibáñez, Borja
Vázquez, Ana
Navarro-Morón, Juan
Ramos-Amador, José-Tomás
Martin-Nalda, Andrea
Dueñas, Eva
Blázquez-Gamero, Daniel
Reques-Cosme, Resurrección
Olabarrieta, Iciar
Prieto, Luis
De Ory, Fernando
Thorne, Claire
Byrne, Thomas
Ades, Anthony E.
Ruiz-Burga, Elisa
Giaquinto, Carlo
Mellado-Peña, María José
García-Alix, Alfredo
Carreras, Elena
Soler-Palacín, Pere
author_sort Soriano-Arandes, Antoni
collection PubMed
description Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.
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spelling pubmed-72813642020-06-19 Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain Soriano-Arandes, Antoni Frick, Marie Antoinette García López-Hortelano, Milagros Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José-Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado-Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere Pathogens Article Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. MDPI 2020-05-07 /pmc/articles/PMC7281364/ /pubmed/32392815 http://dx.doi.org/10.3390/pathogens9050352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soriano-Arandes, Antoni
Frick, Marie Antoinette
García López-Hortelano, Milagros
Sulleiro, Elena
Rodó, Carlota
Sánchez-Seco, María Paz
Cabrera-Lafuente, Marta
Suy, Anna
De la Calle, María
Santos, Mar
Antolin, Eugenia
Viñuela, María del Carmen
Espiau, María
Salazar, Ainara
Guarch-Ibáñez, Borja
Vázquez, Ana
Navarro-Morón, Juan
Ramos-Amador, José-Tomás
Martin-Nalda, Andrea
Dueñas, Eva
Blázquez-Gamero, Daniel
Reques-Cosme, Resurrección
Olabarrieta, Iciar
Prieto, Luis
De Ory, Fernando
Thorne, Claire
Byrne, Thomas
Ades, Anthony E.
Ruiz-Burga, Elisa
Giaquinto, Carlo
Mellado-Peña, María José
García-Alix, Alfredo
Carreras, Elena
Soler-Palacín, Pere
Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
title Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
title_full Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
title_fullStr Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
title_full_unstemmed Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
title_short Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
title_sort clinical outcomes of a zika virus mother–child pair cohort in spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281364/
https://www.ncbi.nlm.nih.gov/pubmed/32392815
http://dx.doi.org/10.3390/pathogens9050352
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