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Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers d...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281364/ https://www.ncbi.nlm.nih.gov/pubmed/32392815 http://dx.doi.org/10.3390/pathogens9050352 |
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author | Soriano-Arandes, Antoni Frick, Marie Antoinette García López-Hortelano, Milagros Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José-Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado-Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere |
author_facet | Soriano-Arandes, Antoni Frick, Marie Antoinette García López-Hortelano, Milagros Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José-Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado-Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere |
author_sort | Soriano-Arandes, Antoni |
collection | PubMed |
description | Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. |
format | Online Article Text |
id | pubmed-7281364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72813642020-06-19 Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain Soriano-Arandes, Antoni Frick, Marie Antoinette García López-Hortelano, Milagros Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José-Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado-Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere Pathogens Article Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. MDPI 2020-05-07 /pmc/articles/PMC7281364/ /pubmed/32392815 http://dx.doi.org/10.3390/pathogens9050352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Soriano-Arandes, Antoni Frick, Marie Antoinette García López-Hortelano, Milagros Sulleiro, Elena Rodó, Carlota Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María Salazar, Ainara Guarch-Ibáñez, Borja Vázquez, Ana Navarro-Morón, Juan Ramos-Amador, José-Tomás Martin-Nalda, Andrea Dueñas, Eva Blázquez-Gamero, Daniel Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa Giaquinto, Carlo Mellado-Peña, María José García-Alix, Alfredo Carreras, Elena Soler-Palacín, Pere Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain |
title | Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain |
title_full | Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain |
title_fullStr | Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain |
title_full_unstemmed | Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain |
title_short | Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain |
title_sort | clinical outcomes of a zika virus mother–child pair cohort in spain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281364/ https://www.ncbi.nlm.nih.gov/pubmed/32392815 http://dx.doi.org/10.3390/pathogens9050352 |
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