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The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer

Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group-Performance status (ECOG...

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Autores principales: Dolan, Ross D., Daly, Louise E., Simmons, Claribel Pl., Ryan, Aoife M., Sim, Wei Mj., Fallon, Marie, Power, Derek G., Wilcock, Andrew, Maddocks, Matthew, Bennett, Michael I., Usborne, Caroline, Laird, Barry J., McMillan, Donald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281405/
https://www.ncbi.nlm.nih.gov/pubmed/32397102
http://dx.doi.org/10.3390/cancers12051187
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author Dolan, Ross D.
Daly, Louise E.
Simmons, Claribel Pl.
Ryan, Aoife M.
Sim, Wei Mj.
Fallon, Marie
Power, Derek G.
Wilcock, Andrew
Maddocks, Matthew
Bennett, Michael I.
Usborne, Caroline
Laird, Barry J.
McMillan, Donald C.
author_facet Dolan, Ross D.
Daly, Louise E.
Simmons, Claribel Pl.
Ryan, Aoife M.
Sim, Wei Mj.
Fallon, Marie
Power, Derek G.
Wilcock, Andrew
Maddocks, Matthew
Bennett, Michael I.
Usborne, Caroline
Laird, Barry J.
McMillan, Donald C.
author_sort Dolan, Ross D.
collection PubMed
description Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group-Performance status (ECOG-PS), modified Glasgow Prognostic Score (mGPS), Body Mass Index/Weight Loss grade (BMI/WL grade), and Computerised Tomography (CT)-derived body composition measurement and physical function in patients with advanced cancer. Nine sites contributed prospective data on patient demographics, ECOG-PS, mGPS, physical function tests, and CT-derived body composition. Categorical variables were analysed using χ(2) test for linear-by-linear association, or χ(2) test for 2-by-2 tables. Associations were analysed using binary logistic regression. A total of 523 cancer patients (266 males, 257 females) were included in the final analysis and most had metastatic disease (83.2%). The median overall survival was 5.6 months. On multivariate binary logistic regression analysis, a high ECOG-PS remained independently associated with a low skeletal muscle index (p < 0.001), low skeletal muscle density (p < 0.05), and timed up and go test failure (p < 0.001). A high mGPS remained independently associated with a low skeletal muscle density (p < 0.05) and hand grip strength test failure (p < 0.01). A high BMI/WL grade remained independently associated with a low subcutaneous fat index (p < 0.05), low visceral obesity (p < 0.01), and low skeletal muscle density (p < 0.05). In conclusion, a high ECOG-PS and a high mGPS as outlined in the ECOG-PS/mGPS framework were consistently associated with poorer body composition and physical function in patients with advanced cancer.
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spelling pubmed-72814052020-06-19 The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer Dolan, Ross D. Daly, Louise E. Simmons, Claribel Pl. Ryan, Aoife M. Sim, Wei Mj. Fallon, Marie Power, Derek G. Wilcock, Andrew Maddocks, Matthew Bennett, Michael I. Usborne, Caroline Laird, Barry J. McMillan, Donald C. Cancers (Basel) Article Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group-Performance status (ECOG-PS), modified Glasgow Prognostic Score (mGPS), Body Mass Index/Weight Loss grade (BMI/WL grade), and Computerised Tomography (CT)-derived body composition measurement and physical function in patients with advanced cancer. Nine sites contributed prospective data on patient demographics, ECOG-PS, mGPS, physical function tests, and CT-derived body composition. Categorical variables were analysed using χ(2) test for linear-by-linear association, or χ(2) test for 2-by-2 tables. Associations were analysed using binary logistic regression. A total of 523 cancer patients (266 males, 257 females) were included in the final analysis and most had metastatic disease (83.2%). The median overall survival was 5.6 months. On multivariate binary logistic regression analysis, a high ECOG-PS remained independently associated with a low skeletal muscle index (p < 0.001), low skeletal muscle density (p < 0.05), and timed up and go test failure (p < 0.001). A high mGPS remained independently associated with a low skeletal muscle density (p < 0.05) and hand grip strength test failure (p < 0.01). A high BMI/WL grade remained independently associated with a low subcutaneous fat index (p < 0.05), low visceral obesity (p < 0.01), and low skeletal muscle density (p < 0.05). In conclusion, a high ECOG-PS and a high mGPS as outlined in the ECOG-PS/mGPS framework were consistently associated with poorer body composition and physical function in patients with advanced cancer. MDPI 2020-05-08 /pmc/articles/PMC7281405/ /pubmed/32397102 http://dx.doi.org/10.3390/cancers12051187 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dolan, Ross D.
Daly, Louise E.
Simmons, Claribel Pl.
Ryan, Aoife M.
Sim, Wei Mj.
Fallon, Marie
Power, Derek G.
Wilcock, Andrew
Maddocks, Matthew
Bennett, Michael I.
Usborne, Caroline
Laird, Barry J.
McMillan, Donald C.
The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
title The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
title_full The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
title_fullStr The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
title_full_unstemmed The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
title_short The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
title_sort relationship between ecog-ps, mgps, bmi/wl grade and body composition and physical function in patients with advanced cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281405/
https://www.ncbi.nlm.nih.gov/pubmed/32397102
http://dx.doi.org/10.3390/cancers12051187
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