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Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?

We examined the associations of Helicobacter pylori and mozuku consumption with fucoidan absorption. Overall, 259 Japanese volunteers consumed 3 g fucoidan, and their urine samples were collected to measure fucoidan values and H. pylori titers before and 3, 6, and 9 h after fucoidan ingestion. Compa...

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Autores principales: Tomori, Makoto, Nagamine, Takeaki, Iha, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281410/
https://www.ncbi.nlm.nih.gov/pubmed/32365934
http://dx.doi.org/10.3390/md18050235
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author Tomori, Makoto
Nagamine, Takeaki
Iha, Masahiko
author_facet Tomori, Makoto
Nagamine, Takeaki
Iha, Masahiko
author_sort Tomori, Makoto
collection PubMed
description We examined the associations of Helicobacter pylori and mozuku consumption with fucoidan absorption. Overall, 259 Japanese volunteers consumed 3 g fucoidan, and their urine samples were collected to measure fucoidan values and H. pylori titers before and 3, 6, and 9 h after fucoidan ingestion. Compared to the basal levels (3.7 ± 3.4 ng/mL), the urinary fucoidan values significantly increased 3, 6, and 9 h (15.3 ± 18.8, 24.4 ± 35.1, and 24.2 ± 35.2 ng/mL, respectively) after fucoidan ingestion. The basal fucoidan levels were significantly lower in H. pylori-negative subjects who rarely ate mozuku than in those who regularly consumed it. Regarding the ΔMax fucoidan value (highest value − basal value) in H. pylori-positive subjects who ate mozuku at least once a month, those aged ≥40 years exhibited significantly lower values than <40 years old. Among subjects ≥40 years old who regularly consumed mozuku, the ΔMax fucoidan value was significantly lower in H. pylori-positive subjects than in H. pylori-negative ones. In H. pylori-positive subjects who ate mozuku at least once monthly, basal fucoidan values displayed positive correlations with H. pylori titers and ΔMax fucoidan values in subjects <40 years old. No correlations were found in H. pylori-positive subjects who ate mozuku once every 2–3 months or less. Thus, fucoidan absorption is associated with H. pylori infection and frequency of mozuku consumption.
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spelling pubmed-72814102020-06-19 Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption? Tomori, Makoto Nagamine, Takeaki Iha, Masahiko Mar Drugs Article We examined the associations of Helicobacter pylori and mozuku consumption with fucoidan absorption. Overall, 259 Japanese volunteers consumed 3 g fucoidan, and their urine samples were collected to measure fucoidan values and H. pylori titers before and 3, 6, and 9 h after fucoidan ingestion. Compared to the basal levels (3.7 ± 3.4 ng/mL), the urinary fucoidan values significantly increased 3, 6, and 9 h (15.3 ± 18.8, 24.4 ± 35.1, and 24.2 ± 35.2 ng/mL, respectively) after fucoidan ingestion. The basal fucoidan levels were significantly lower in H. pylori-negative subjects who rarely ate mozuku than in those who regularly consumed it. Regarding the ΔMax fucoidan value (highest value − basal value) in H. pylori-positive subjects who ate mozuku at least once a month, those aged ≥40 years exhibited significantly lower values than <40 years old. Among subjects ≥40 years old who regularly consumed mozuku, the ΔMax fucoidan value was significantly lower in H. pylori-positive subjects than in H. pylori-negative ones. In H. pylori-positive subjects who ate mozuku at least once monthly, basal fucoidan values displayed positive correlations with H. pylori titers and ΔMax fucoidan values in subjects <40 years old. No correlations were found in H. pylori-positive subjects who ate mozuku once every 2–3 months or less. Thus, fucoidan absorption is associated with H. pylori infection and frequency of mozuku consumption. MDPI 2020-04-30 /pmc/articles/PMC7281410/ /pubmed/32365934 http://dx.doi.org/10.3390/md18050235 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tomori, Makoto
Nagamine, Takeaki
Iha, Masahiko
Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?
title Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?
title_full Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?
title_fullStr Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?
title_full_unstemmed Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?
title_short Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?
title_sort are helicobacter pylori infection and fucoidan consumption associated with fucoidan absorption?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281410/
https://www.ncbi.nlm.nih.gov/pubmed/32365934
http://dx.doi.org/10.3390/md18050235
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