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Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration
In recent years, the use of natural killer (NK) cell-based immunotherapy has shown promise against various cancer types. To some extent therapeutic potential of NK cell-based immunotherapy depends on migration of NK cells towards tumors in animal models or human subjects and subsequent infiltration....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281416/ https://www.ncbi.nlm.nih.gov/pubmed/32455886 http://dx.doi.org/10.3390/cancers12051318 |
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author | Gangadaran, Prakash Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol |
author_facet | Gangadaran, Prakash Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol |
author_sort | Gangadaran, Prakash |
collection | PubMed |
description | In recent years, the use of natural killer (NK) cell-based immunotherapy has shown promise against various cancer types. To some extent therapeutic potential of NK cell-based immunotherapy depends on migration of NK cells towards tumors in animal models or human subjects and subsequent infiltration. Constant improvement in the pharmacological and therapeutic properties of NK cells is driving the performance and use of NK cell-based immunotherapies. In this review, we summarize the molecular imaging techniques used in monitoring the migration and infiltration of NK cells in vivo at preclinical and clinical levels. A review of pros and cons of each molecular imaging modality is done. Finally, we provide our perception of the usefulness of molecular imaging approaches for in vivo monitoring of NK cells in preclinical and clinical scenarios. |
format | Online Article Text |
id | pubmed-7281416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72814162020-06-19 Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration Gangadaran, Prakash Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol Cancers (Basel) Review In recent years, the use of natural killer (NK) cell-based immunotherapy has shown promise against various cancer types. To some extent therapeutic potential of NK cell-based immunotherapy depends on migration of NK cells towards tumors in animal models or human subjects and subsequent infiltration. Constant improvement in the pharmacological and therapeutic properties of NK cells is driving the performance and use of NK cell-based immunotherapies. In this review, we summarize the molecular imaging techniques used in monitoring the migration and infiltration of NK cells in vivo at preclinical and clinical levels. A review of pros and cons of each molecular imaging modality is done. Finally, we provide our perception of the usefulness of molecular imaging approaches for in vivo monitoring of NK cells in preclinical and clinical scenarios. MDPI 2020-05-22 /pmc/articles/PMC7281416/ /pubmed/32455886 http://dx.doi.org/10.3390/cancers12051318 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gangadaran, Prakash Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration |
title | Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration |
title_full | Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration |
title_fullStr | Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration |
title_full_unstemmed | Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration |
title_short | Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration |
title_sort | application of in vivo imaging techniques for monitoring natural killer cell migration and tumor infiltration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281416/ https://www.ncbi.nlm.nih.gov/pubmed/32455886 http://dx.doi.org/10.3390/cancers12051318 |
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