Germline Mutation in MUS81 Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer

Multiple primary thyroid cancer (TC) and breast cancer (BC) are commonly diagnosed, and the lifetime risk for these cancers is increased in patients with a positive family history of both TC and BC. Although this phenotype is partially explained by TP53 or PTEN mutations, a significant number of pat...

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Detalles Bibliográficos
Autores principales: Pinheiro, Maisa, Lupinacci, Fernanda Cristina Sulla, Santiago, Karina Miranda, Drigo, Sandra Aparecida, Marchi, Fabio Albuquerque, Fonseca-Alves, Carlos Eduardo, Andrade, Sonia Cristina da Silva, Aagaard, Mads Malik, Basso, Tatiane Ramos, dos Reis, Mariana Bisarro, Villacis, Rolando André Rios, Roffé, Martin, Hajj, Glaucia Noeli Maroso, Jurisica, Igor, Kowalski, Luiz Paulo, Achatz, Maria Isabel, Rogatto, Silvia Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281423/
https://www.ncbi.nlm.nih.gov/pubmed/32443704
http://dx.doi.org/10.3390/cancers12051289

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