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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

Src family kinases (SFKs) are non-receptor kinases that play a critical role in the pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are upregulated in patients with CRC. Activation of SFKs promotes CRC cell proliferation, metastases to other organs and chemoresistance, a...

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Detalles Bibliográficos
Autor principal: Jin, Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281431/
https://www.ncbi.nlm.nih.gov/pubmed/32456226
http://dx.doi.org/10.3390/cancers12051339
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author Jin, Wook
author_facet Jin, Wook
author_sort Jin, Wook
collection PubMed
description Src family kinases (SFKs) are non-receptor kinases that play a critical role in the pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are upregulated in patients with CRC. Activation of SFKs promotes CRC cell proliferation, metastases to other organs and chemoresistance, as well as the formation of cancer stem cells (CSCs). The enhanced expression level of Src is associated with decreased survival in patients with CRC. Src-mediated regulation of CRC progression involves various membrane receptors, modulators, and suppressors, which regulate Src activation and its downstream targets through various mechanisms. This review provides an overview of the current understanding of the correlations between Src and CRC progression, with a special focus on cancer cell proliferation, invasion, metastasis and chemoresistance, and formation of CSCs. Additionally, this review discusses preclinical and clinical strategies to improve the therapeutic efficacy of drugs targeting Src for treating patients with CRC.
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spelling pubmed-72814312020-06-19 Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications Jin, Wook Cancers (Basel) Review Src family kinases (SFKs) are non-receptor kinases that play a critical role in the pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are upregulated in patients with CRC. Activation of SFKs promotes CRC cell proliferation, metastases to other organs and chemoresistance, as well as the formation of cancer stem cells (CSCs). The enhanced expression level of Src is associated with decreased survival in patients with CRC. Src-mediated regulation of CRC progression involves various membrane receptors, modulators, and suppressors, which regulate Src activation and its downstream targets through various mechanisms. This review provides an overview of the current understanding of the correlations between Src and CRC progression, with a special focus on cancer cell proliferation, invasion, metastasis and chemoresistance, and formation of CSCs. Additionally, this review discusses preclinical and clinical strategies to improve the therapeutic efficacy of drugs targeting Src for treating patients with CRC. MDPI 2020-05-23 /pmc/articles/PMC7281431/ /pubmed/32456226 http://dx.doi.org/10.3390/cancers12051339 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jin, Wook
Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
title Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
title_full Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
title_fullStr Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
title_full_unstemmed Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
title_short Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
title_sort regulation of src family kinases during colorectal cancer development and its clinical implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281431/
https://www.ncbi.nlm.nih.gov/pubmed/32456226
http://dx.doi.org/10.3390/cancers12051339
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