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Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer
Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both reg...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281445/ https://www.ncbi.nlm.nih.gov/pubmed/32365592 http://dx.doi.org/10.3390/cancers12051113 |
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author | Lafont, Elodie |
author_facet | Lafont, Elodie |
author_sort | Lafont, Elodie |
collection | PubMed |
description | Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both regulate a plethora of outcomes, ranging from proliferation, differentiation, migration, cytokine production to the induction of cell death. Both signallings are major modulators of physiological tissue homeostasis and their dysregulation is involved in tumorigenesis and the metastastic process. The molecular determinants of the control between the different cellular outcomes induced by DR signalling and the UPR in tumour cells and their stroma and their consequences on tumorigenesis are starting to be unravelled. Herein, I summarize the main steps of DR signalling in relation to its cellular and pathophysiological roles in cancer. I then highlight how the UPR and DR signalling control common cellular outcomes and also cross-talk, providing potential opportunities to further understand the development of malignancies. |
format | Online Article Text |
id | pubmed-7281445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72814452020-06-19 Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer Lafont, Elodie Cancers (Basel) Review Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both regulate a plethora of outcomes, ranging from proliferation, differentiation, migration, cytokine production to the induction of cell death. Both signallings are major modulators of physiological tissue homeostasis and their dysregulation is involved in tumorigenesis and the metastastic process. The molecular determinants of the control between the different cellular outcomes induced by DR signalling and the UPR in tumour cells and their stroma and their consequences on tumorigenesis are starting to be unravelled. Herein, I summarize the main steps of DR signalling in relation to its cellular and pathophysiological roles in cancer. I then highlight how the UPR and DR signalling control common cellular outcomes and also cross-talk, providing potential opportunities to further understand the development of malignancies. MDPI 2020-04-29 /pmc/articles/PMC7281445/ /pubmed/32365592 http://dx.doi.org/10.3390/cancers12051113 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lafont, Elodie Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer |
title | Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer |
title_full | Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer |
title_fullStr | Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer |
title_full_unstemmed | Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer |
title_short | Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer |
title_sort | stress management: death receptor signalling and cross-talks with the unfolded protein response in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281445/ https://www.ncbi.nlm.nih.gov/pubmed/32365592 http://dx.doi.org/10.3390/cancers12051113 |
work_keys_str_mv | AT lafontelodie stressmanagementdeathreceptorsignallingandcrosstalkswiththeunfoldedproteinresponseincancer |