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Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis

The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field du...

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Autores principales: Kaźmierczak-Siedlecka, Karolina, Dvořák, Aleš, Folwarski, Marcin, Daca, Agnieszka, Przewłócka, Katarzyna, Makarewicz, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281455/
https://www.ncbi.nlm.nih.gov/pubmed/32455985
http://dx.doi.org/10.3390/cancers12051326
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author Kaźmierczak-Siedlecka, Karolina
Dvořák, Aleš
Folwarski, Marcin
Daca, Agnieszka
Przewłócka, Katarzyna
Makarewicz, Wojciech
author_facet Kaźmierczak-Siedlecka, Karolina
Dvořák, Aleš
Folwarski, Marcin
Daca, Agnieszka
Przewłócka, Katarzyna
Makarewicz, Wojciech
author_sort Kaźmierczak-Siedlecka, Karolina
collection PubMed
description The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field due to low abundance of intestinal fungi as well as lack of well-characterized reference genomes. Several specific fungi amounts are increased in colorectal cancer patients; moreover, it was observed that the disease stage is strongly related to the fungal microbiota profile; thus, it may be used as a potential diagnostic biomarker for adenomas. Candida albicans, which is the major microbe contributing to oral cancer development, may promote carcinogenesis via several mechanisms, mainly triggering inflammation. Early detection of pancreatic cancer provides the opportunity to improve survival rate, therefore, there is a need to conduct further studies regarding the role of fungal microbiota as a potential prognostic tool to diagnose this cancer at early stage. Additionally, growing attention towards the characterization of mycobiota may contribute to improve the efficiency of therapeutic methods used to alter the composition and activity of gut microbiota. The administration of Saccharomyces boulardii in oncology, mainly in immunocompromised and/or critically ill patients, is still controversial.
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spelling pubmed-72814552020-06-19 Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis Kaźmierczak-Siedlecka, Karolina Dvořák, Aleš Folwarski, Marcin Daca, Agnieszka Przewłócka, Katarzyna Makarewicz, Wojciech Cancers (Basel) Review The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field due to low abundance of intestinal fungi as well as lack of well-characterized reference genomes. Several specific fungi amounts are increased in colorectal cancer patients; moreover, it was observed that the disease stage is strongly related to the fungal microbiota profile; thus, it may be used as a potential diagnostic biomarker for adenomas. Candida albicans, which is the major microbe contributing to oral cancer development, may promote carcinogenesis via several mechanisms, mainly triggering inflammation. Early detection of pancreatic cancer provides the opportunity to improve survival rate, therefore, there is a need to conduct further studies regarding the role of fungal microbiota as a potential prognostic tool to diagnose this cancer at early stage. Additionally, growing attention towards the characterization of mycobiota may contribute to improve the efficiency of therapeutic methods used to alter the composition and activity of gut microbiota. The administration of Saccharomyces boulardii in oncology, mainly in immunocompromised and/or critically ill patients, is still controversial. MDPI 2020-05-22 /pmc/articles/PMC7281455/ /pubmed/32455985 http://dx.doi.org/10.3390/cancers12051326 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaźmierczak-Siedlecka, Karolina
Dvořák, Aleš
Folwarski, Marcin
Daca, Agnieszka
Przewłócka, Katarzyna
Makarewicz, Wojciech
Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
title Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
title_full Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
title_fullStr Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
title_full_unstemmed Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
title_short Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
title_sort fungal gut microbiota dysbiosis and its role in colorectal, oral, and pancreatic carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281455/
https://www.ncbi.nlm.nih.gov/pubmed/32455985
http://dx.doi.org/10.3390/cancers12051326
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