Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205

Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A–C (3–5) were identified from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication,” which deleted the highly expressed secondary metabolite-enterocin biosynthetic...

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Detalles Bibliográficos
Autores principales: Xu, Dongbo, Tian, Erli, Kong, Fandong, Hong, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281499/
https://www.ncbi.nlm.nih.gov/pubmed/32414163
http://dx.doi.org/10.3390/md18050255
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author Xu, Dongbo
Tian, Erli
Kong, Fandong
Hong, Kui
author_facet Xu, Dongbo
Tian, Erli
Kong, Fandong
Hong, Kui
author_sort Xu, Dongbo
collection PubMed
description Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A–C (3–5) were identified from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication,” which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 2–4 showed weak antiproliferative activities.
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spelling pubmed-72814992020-06-17 Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205 Xu, Dongbo Tian, Erli Kong, Fandong Hong, Kui Mar Drugs Article Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A–C (3–5) were identified from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication,” which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 2–4 showed weak antiproliferative activities. MDPI 2020-05-13 /pmc/articles/PMC7281499/ /pubmed/32414163 http://dx.doi.org/10.3390/md18050255 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Dongbo
Tian, Erli
Kong, Fandong
Hong, Kui
Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
title Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
title_full Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
title_fullStr Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
title_full_unstemmed Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
title_short Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
title_sort bioactive molecules from mangrove streptomyces qinglanensis 172205
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281499/
https://www.ncbi.nlm.nih.gov/pubmed/32414163
http://dx.doi.org/10.3390/md18050255
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