Rare Neurologic Disease-Associated Mutations of AIMP1 Are Related with Inhibitory Neuronal Differentiation Which Is Reversed by Ibuprofen

Background: Hypomyelinating leukodystrophy 3 (HLD3), previously characterized as a congenital diseases associated with oligodendrocyte myelination, is increasingly regarded as primarily affecting neuronal cells. Methods: We used N1E-115 cells as the neuronal cell model to investigate whether HLD3-as...

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Detalles Bibliográficos
Autores principales: Takeuchi, Yu, Tanaka, Marina, Okura, Nanako, Fukui, Yasuyuki, Noguchi, Ko, Hayashi, Yoshihiro, Torii, Tomohiro, Ooizumi, Hiroaki, Ohbuchi, Katsuya, Mizoguchi, Kazushige, Miyamoto, Yuki, Yamauchi, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281511/
https://www.ncbi.nlm.nih.gov/pubmed/32384815
http://dx.doi.org/10.3390/medicines7050025

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