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Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model

Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung p...

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Autores principales: Richards, Claire, Williams, Neil A., Fitton, J. Helen, Stringer, Damien N., Karpiniec, Samuel S., Park, Ah Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281568/
https://www.ncbi.nlm.nih.gov/pubmed/32397317
http://dx.doi.org/10.3390/md18050246
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author Richards, Claire
Williams, Neil A.
Fitton, J. Helen
Stringer, Damien N.
Karpiniec, Samuel S.
Park, Ah Young
author_facet Richards, Claire
Williams, Neil A.
Fitton, J. Helen
Stringer, Damien N.
Karpiniec, Samuel S.
Park, Ah Young
author_sort Richards, Claire
collection PubMed
description Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung pathology (consolidation) was significantly reduced as compared to controls. UPF was then presented as a feed supplement at a rate of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection. A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres.
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spelling pubmed-72815682020-06-17 Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model Richards, Claire Williams, Neil A. Fitton, J. Helen Stringer, Damien N. Karpiniec, Samuel S. Park, Ah Young Mar Drugs Communication Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung pathology (consolidation) was significantly reduced as compared to controls. UPF was then presented as a feed supplement at a rate of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection. A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres. MDPI 2020-05-08 /pmc/articles/PMC7281568/ /pubmed/32397317 http://dx.doi.org/10.3390/md18050246 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Richards, Claire
Williams, Neil A.
Fitton, J. Helen
Stringer, Damien N.
Karpiniec, Samuel S.
Park, Ah Young
Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
title Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
title_full Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
title_fullStr Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
title_full_unstemmed Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
title_short Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
title_sort oral fucoidan attenuates lung pathology and clinical signs in a severe influenza a mouse model
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281568/
https://www.ncbi.nlm.nih.gov/pubmed/32397317
http://dx.doi.org/10.3390/md18050246
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