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Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model
Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281568/ https://www.ncbi.nlm.nih.gov/pubmed/32397317 http://dx.doi.org/10.3390/md18050246 |
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author | Richards, Claire Williams, Neil A. Fitton, J. Helen Stringer, Damien N. Karpiniec, Samuel S. Park, Ah Young |
author_facet | Richards, Claire Williams, Neil A. Fitton, J. Helen Stringer, Damien N. Karpiniec, Samuel S. Park, Ah Young |
author_sort | Richards, Claire |
collection | PubMed |
description | Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung pathology (consolidation) was significantly reduced as compared to controls. UPF was then presented as a feed supplement at a rate of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection. A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres. |
format | Online Article Text |
id | pubmed-7281568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72815682020-06-17 Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model Richards, Claire Williams, Neil A. Fitton, J. Helen Stringer, Damien N. Karpiniec, Samuel S. Park, Ah Young Mar Drugs Communication Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung pathology (consolidation) was significantly reduced as compared to controls. UPF was then presented as a feed supplement at a rate of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection. A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres. MDPI 2020-05-08 /pmc/articles/PMC7281568/ /pubmed/32397317 http://dx.doi.org/10.3390/md18050246 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Richards, Claire Williams, Neil A. Fitton, J. Helen Stringer, Damien N. Karpiniec, Samuel S. Park, Ah Young Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model |
title | Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model |
title_full | Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model |
title_fullStr | Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model |
title_full_unstemmed | Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model |
title_short | Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model |
title_sort | oral fucoidan attenuates lung pathology and clinical signs in a severe influenza a mouse model |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281568/ https://www.ncbi.nlm.nih.gov/pubmed/32397317 http://dx.doi.org/10.3390/md18050246 |
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