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Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a highe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281576/ https://www.ncbi.nlm.nih.gov/pubmed/32344907 http://dx.doi.org/10.3390/cancers12051069 |
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author | Kofler, Barbara Borena, Wegene Dudas, Jozsef Innerhofer, Veronika Dejaco, Daniel Steinbichler, Teresa B Widmann, Gerlig von Laer, Dorothee Riechelmann, Herbert |
author_facet | Kofler, Barbara Borena, Wegene Dudas, Jozsef Innerhofer, Veronika Dejaco, Daniel Steinbichler, Teresa B Widmann, Gerlig von Laer, Dorothee Riechelmann, Herbert |
author_sort | Kofler, Barbara |
collection | PubMed |
description | Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a higher recurrence rate. Following the end of treatment of patients with initially hr-HPV positive OPSCC, surface brushings from the previous tumor site were performed and tested for hr-HPV DNA. Of 62 patients with initially hr-HPV DNA-positive OPSCC, seven patients remained hr-HPV-DNA positive at post-treatment follow-up. Of the seven hr-HPV-positive patients at follow-up, five had a tumor relapse or tumor progression, of whom three died. The majority of patients (55/62) was HPV-negative following treatment. All HPV-negative patients remained free of disease (p = 0.0007). In this study, all patients with recurrence were hr-HPV-positive with the same genotype as that before treatment. In patients who were hr-HPV negative after treatment, no recurrence was observed. |
format | Online Article Text |
id | pubmed-7281576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72815762020-06-17 Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma Kofler, Barbara Borena, Wegene Dudas, Jozsef Innerhofer, Veronika Dejaco, Daniel Steinbichler, Teresa B Widmann, Gerlig von Laer, Dorothee Riechelmann, Herbert Cancers (Basel) Article Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a higher recurrence rate. Following the end of treatment of patients with initially hr-HPV positive OPSCC, surface brushings from the previous tumor site were performed and tested for hr-HPV DNA. Of 62 patients with initially hr-HPV DNA-positive OPSCC, seven patients remained hr-HPV-DNA positive at post-treatment follow-up. Of the seven hr-HPV-positive patients at follow-up, five had a tumor relapse or tumor progression, of whom three died. The majority of patients (55/62) was HPV-negative following treatment. All HPV-negative patients remained free of disease (p = 0.0007). In this study, all patients with recurrence were hr-HPV-positive with the same genotype as that before treatment. In patients who were hr-HPV negative after treatment, no recurrence was observed. MDPI 2020-04-25 /pmc/articles/PMC7281576/ /pubmed/32344907 http://dx.doi.org/10.3390/cancers12051069 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kofler, Barbara Borena, Wegene Dudas, Jozsef Innerhofer, Veronika Dejaco, Daniel Steinbichler, Teresa B Widmann, Gerlig von Laer, Dorothee Riechelmann, Herbert Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma |
title | Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma |
title_full | Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma |
title_fullStr | Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma |
title_full_unstemmed | Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma |
title_short | Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma |
title_sort | post-treatment hpv surface brushings and risk of relapse in oropharyngeal carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281576/ https://www.ncbi.nlm.nih.gov/pubmed/32344907 http://dx.doi.org/10.3390/cancers12051069 |
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