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Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma

Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a highe...

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Autores principales: Kofler, Barbara, Borena, Wegene, Dudas, Jozsef, Innerhofer, Veronika, Dejaco, Daniel, Steinbichler, Teresa B, Widmann, Gerlig, von Laer, Dorothee, Riechelmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281576/
https://www.ncbi.nlm.nih.gov/pubmed/32344907
http://dx.doi.org/10.3390/cancers12051069
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author Kofler, Barbara
Borena, Wegene
Dudas, Jozsef
Innerhofer, Veronika
Dejaco, Daniel
Steinbichler, Teresa B
Widmann, Gerlig
von Laer, Dorothee
Riechelmann, Herbert
author_facet Kofler, Barbara
Borena, Wegene
Dudas, Jozsef
Innerhofer, Veronika
Dejaco, Daniel
Steinbichler, Teresa B
Widmann, Gerlig
von Laer, Dorothee
Riechelmann, Herbert
author_sort Kofler, Barbara
collection PubMed
description Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a higher recurrence rate. Following the end of treatment of patients with initially hr-HPV positive OPSCC, surface brushings from the previous tumor site were performed and tested for hr-HPV DNA. Of 62 patients with initially hr-HPV DNA-positive OPSCC, seven patients remained hr-HPV-DNA positive at post-treatment follow-up. Of the seven hr-HPV-positive patients at follow-up, five had a tumor relapse or tumor progression, of whom three died. The majority of patients (55/62) was HPV-negative following treatment. All HPV-negative patients remained free of disease (p = 0.0007). In this study, all patients with recurrence were hr-HPV-positive with the same genotype as that before treatment. In patients who were hr-HPV negative after treatment, no recurrence was observed.
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spelling pubmed-72815762020-06-17 Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma Kofler, Barbara Borena, Wegene Dudas, Jozsef Innerhofer, Veronika Dejaco, Daniel Steinbichler, Teresa B Widmann, Gerlig von Laer, Dorothee Riechelmann, Herbert Cancers (Basel) Article Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a higher recurrence rate. Following the end of treatment of patients with initially hr-HPV positive OPSCC, surface brushings from the previous tumor site were performed and tested for hr-HPV DNA. Of 62 patients with initially hr-HPV DNA-positive OPSCC, seven patients remained hr-HPV-DNA positive at post-treatment follow-up. Of the seven hr-HPV-positive patients at follow-up, five had a tumor relapse or tumor progression, of whom three died. The majority of patients (55/62) was HPV-negative following treatment. All HPV-negative patients remained free of disease (p = 0.0007). In this study, all patients with recurrence were hr-HPV-positive with the same genotype as that before treatment. In patients who were hr-HPV negative after treatment, no recurrence was observed. MDPI 2020-04-25 /pmc/articles/PMC7281576/ /pubmed/32344907 http://dx.doi.org/10.3390/cancers12051069 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kofler, Barbara
Borena, Wegene
Dudas, Jozsef
Innerhofer, Veronika
Dejaco, Daniel
Steinbichler, Teresa B
Widmann, Gerlig
von Laer, Dorothee
Riechelmann, Herbert
Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
title Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
title_full Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
title_fullStr Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
title_full_unstemmed Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
title_short Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma
title_sort post-treatment hpv surface brushings and risk of relapse in oropharyngeal carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281576/
https://www.ncbi.nlm.nih.gov/pubmed/32344907
http://dx.doi.org/10.3390/cancers12051069
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