Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors

This study examined the role of the ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets in glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with i...

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Detalles Bibliográficos
Autores principales: Wang, Xiaowen, Bustos, Matias A., Zhang, Xiaoqing, Ramos, Romela Irene, Tan, Cong, Iida, Yuuki, Chang, Shu-Ching, Salomon, Matthew P., Tran, Kevin, Gentry, Rebecca, Kravtsova-Ivantsiv, Yelena, Kelly, Daniel F., Mills, Gordon B., Ciechanover, Aaron, Mao, Ying, Hoon, Dave S.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281601/
https://www.ncbi.nlm.nih.gov/pubmed/32349217
http://dx.doi.org/10.3390/cancers12051081

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