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A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approac...

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Autores principales: Motais, Benjamin, Charvátová, Sandra, Hrdinka, Matouš, Šimíček, Michal, Jelínek, Tomáš, Ševčíková, Tereza, Kořístek, Zdeněk, Hájek, Roman, Bagó, Juli R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281611/
https://www.ncbi.nlm.nih.gov/pubmed/32456165
http://dx.doi.org/10.3390/cancers12051333
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author Motais, Benjamin
Charvátová, Sandra
Hrdinka, Matouš
Šimíček, Michal
Jelínek, Tomáš
Ševčíková, Tereza
Kořístek, Zdeněk
Hájek, Roman
Bagó, Juli R.
author_facet Motais, Benjamin
Charvátová, Sandra
Hrdinka, Matouš
Šimíček, Michal
Jelínek, Tomáš
Ševčíková, Tereza
Kořístek, Zdeněk
Hájek, Roman
Bagó, Juli R.
author_sort Motais, Benjamin
collection PubMed
description Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.
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spelling pubmed-72816112020-06-17 A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers Motais, Benjamin Charvátová, Sandra Hrdinka, Matouš Šimíček, Michal Jelínek, Tomáš Ševčíková, Tereza Kořístek, Zdeněk Hájek, Roman Bagó, Juli R. Cancers (Basel) Review Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source. MDPI 2020-05-23 /pmc/articles/PMC7281611/ /pubmed/32456165 http://dx.doi.org/10.3390/cancers12051333 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Motais, Benjamin
Charvátová, Sandra
Hrdinka, Matouš
Šimíček, Michal
Jelínek, Tomáš
Ševčíková, Tereza
Kořístek, Zdeněk
Hájek, Roman
Bagó, Juli R.
A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
title A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
title_full A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
title_fullStr A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
title_full_unstemmed A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
title_short A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
title_sort bird’s-eye view of cell sources for cell-based therapies in blood cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281611/
https://www.ncbi.nlm.nih.gov/pubmed/32456165
http://dx.doi.org/10.3390/cancers12051333
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