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A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approac...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281611/ https://www.ncbi.nlm.nih.gov/pubmed/32456165 http://dx.doi.org/10.3390/cancers12051333 |
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author | Motais, Benjamin Charvátová, Sandra Hrdinka, Matouš Šimíček, Michal Jelínek, Tomáš Ševčíková, Tereza Kořístek, Zdeněk Hájek, Roman Bagó, Juli R. |
author_facet | Motais, Benjamin Charvátová, Sandra Hrdinka, Matouš Šimíček, Michal Jelínek, Tomáš Ševčíková, Tereza Kořístek, Zdeněk Hájek, Roman Bagó, Juli R. |
author_sort | Motais, Benjamin |
collection | PubMed |
description | Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source. |
format | Online Article Text |
id | pubmed-7281611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72816112020-06-17 A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers Motais, Benjamin Charvátová, Sandra Hrdinka, Matouš Šimíček, Michal Jelínek, Tomáš Ševčíková, Tereza Kořístek, Zdeněk Hájek, Roman Bagó, Juli R. Cancers (Basel) Review Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source. MDPI 2020-05-23 /pmc/articles/PMC7281611/ /pubmed/32456165 http://dx.doi.org/10.3390/cancers12051333 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Motais, Benjamin Charvátová, Sandra Hrdinka, Matouš Šimíček, Michal Jelínek, Tomáš Ševčíková, Tereza Kořístek, Zdeněk Hájek, Roman Bagó, Juli R. A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers |
title | A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers |
title_full | A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers |
title_fullStr | A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers |
title_full_unstemmed | A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers |
title_short | A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers |
title_sort | bird’s-eye view of cell sources for cell-based therapies in blood cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281611/ https://www.ncbi.nlm.nih.gov/pubmed/32456165 http://dx.doi.org/10.3390/cancers12051333 |
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