Cargando…

Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells

Tetraploidy, or whole-genome duplication, is a common phenomenon in cancer and preludes chromosome instability, which strongly correlates with disease progression, metastasis, and treatment failure. Therefore, it is reasonable to hypothesize that tetraploidization confers multidrug resistance. Never...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galofré, Claudia, Gönül Geyik, Öykü, Asensio, Elena, Wangsa, Darawalee, Hirsch, Daniela, Parra, Carolina, Saez, Jordi, Mollà, Meritxell, Yüce, Zeynep, Castells, Antoni, Ried, Thomas, Camps, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281619/ https://www.ncbi.nlm.nih.gov/pubmed/32365785 http://dx.doi.org/10.3390/cancers12051118

Ejemplares similares

Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion
por: Galofré, Claudia, et al.
Publicado: (2020)

Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases
por: Rausch, Valentin, et al.
Publicado: (2017)

Chromosome mis-segregation and cytokinesis failure in trisomic human cells
por: Nicholson, Joshua M, et al.
Publicado: (2015)

Development of tetraploidy in salmonids
por: Refstie, T
Publicado: (1980)

Tetraploidy and tumor development
por: Lim, Sanghee, et al.
Publicado: (2014)

Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes
por: Bowen, Steven, et al.
Publicado: (2013)

Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells
por: Baykal-Köse, Seda, et al.
Publicado: (2020)

Neuronal tetraploidy in Alzheimer and aging
por: Frade, José M., et al.
Publicado: (2017)

CKAP2 Ensures Chromosomal Stability by Maintaining the Integrity of Microtubule Nucleation Sites
por: Case, Chanelle M., et al.
Publicado: (2013)

Tetraploidy in cancer and its possible link to aging
por: Tanaka, Kozo, et al.
Publicado: (2018)

Induction, identification and characterization of tetraploidy in Lycium ruthenicum
por: Rao, Shupei, et al.
Publicado: (2019)

DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives
por: Gönül Geyik, Öykü, et al.
Publicado: (2022)

Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling
por: Achyut, B. R., et al.
Publicado: (2013)

An Improved Breast Epithelial Sampling Method for Molecular Profiling and Biomarker Analysis in Women at Risk for Breast Cancer
por: Danforth, David N, et al.
Publicado: (2015)

Inferring models of multiscale copy number evolution for single-tumor phylogenetics
por: Chowdhury, Salim Akhter, et al.
Publicado: (2015)

Doubling the deck: Tetraploidy induces chromosome shuffling and cancer
por: Nicholson, Joshua M., et al.
Publicado: (2012)

Tetraploidy-associated centrosome overduplication in mouse early embryos
por: Yaguchi, Kan, et al.
Publicado: (2018)

Tetraploidy causes chromosomal instability in acentriolar mouse embryos
por: Paim, Lia Mara Gomes, et al.
Publicado: (2019)

The consequences of tetraploidy on Caenorhabditis elegans physiology and sensitivity to chemotherapeutics
por: Misare, Kelly R., et al.
Publicado: (2023)

The consequences of tetraploidy on Caenorhabditis elegans physiology and sensitivity to chemotherapeutics
por: Misare, Kelly R., et al.
Publicado: (2023)

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies
por: Patkar, Sushant, et al.
Publicado: (2021)

Two Cases of Near-Tetraploidy in Acute Leukemias of Ambiguous Lineage
por: Kim, Bo Hyun, et al.
Publicado: (2013)

Genetic differentiation and spatiotemporal history of diploidy and tetraploidy of Clintonia udensis
por: He, Juan, et al.
Publicado: (2017)

Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
por: Yoshizawa, Koya, et al.
Publicado: (2023)

Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells()
por: Wangsa, Darawalee, et al.
Publicado: (2019)

Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression
por: Braun, Rüdiger, et al.
Publicado: (2019)

FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe
por: Gertz, E. Michael, et al.
Publicado: (2016)

MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells
por: Xie, Yili, et al.
Publicado: (2012)

Stimulation of Cell Elongation by Tetraploidy in Hypocotyls of Dark-Grown Arabidopsis Seedlings
por: Narukawa, Hideki, et al.
Publicado: (2015)

miR-186 induces tetraploidy in arsenic exposed human keratinocytes
por: Ferragut Cardoso, Ana P., et al.
Publicado: (2023)

Tetraploidy accelerates adaptation under drug selection in a fungal pathogen
por: Avramovska, Ognenka, et al.
Publicado: (2022)

In vitro induction of tetraploidy and its effects on phenotypic variations in Populus hopeiensis
por: Wu, Jian, et al.
Publicado: (2023)

Effects of human sex chromosome dosage on spatial chromosome organization
por: Jowhar, Ziad, et al.
Publicado: (2018)

A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug
por: Chen, Chen, et al.
Publicado: (2017)

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
por: Sciascia, Nicholas, et al.
Publicado: (2020)

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure
por: Wong, Connie, et al.
Publicado: (2005)

DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development
por: Ichijima, Yosuke, et al.
Publicado: (2010)

Acute Myeloid Leukemia with Philadelphia Chromosome, Near-tetraploidy, and 5q Deletion
por: Khan, Abdul Moiz, et al.
Publicado: (2019)

Successful treatment of primary cutaneous angiosarcoma of the nose with sequential chemo- and radiotherapy
por: Herrscher, H., et al.
Publicado: (2019)

The characterisation of microsatellite markers reveals tetraploidy in the Greater Water Parsnip, Sium latifolium (Apiaceae)
por: Dalton, Naomi J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sr9g2clmk5i85mnr0r2t6jbim7