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miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis

Epstein-Barr virus (EBV) or human herpesvirus 4 (HHV-4) is a ubiquitous human oncogenic virus, and the first human virus found to express microRNAs (miRNAs). Its genome contains two regions encoding more than 40 miRNAs that regulate expression of both viral and human genes. There are numerous eviden...

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Autores principales: Židovec Lepej, Snježana, Matulić, Maja, Gršković, Paula, Pavlica, Mirjana, Radmanić, Leona, Korać, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281681/
https://www.ncbi.nlm.nih.gov/pubmed/32397085
http://dx.doi.org/10.3390/pathogens9050353
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author Židovec Lepej, Snježana
Matulić, Maja
Gršković, Paula
Pavlica, Mirjana
Radmanić, Leona
Korać, Petra
author_facet Židovec Lepej, Snježana
Matulić, Maja
Gršković, Paula
Pavlica, Mirjana
Radmanić, Leona
Korać, Petra
author_sort Židovec Lepej, Snježana
collection PubMed
description Epstein-Barr virus (EBV) or human herpesvirus 4 (HHV-4) is a ubiquitous human oncogenic virus, and the first human virus found to express microRNAs (miRNAs). Its genome contains two regions encoding more than 40 miRNAs that regulate expression of both viral and human genes. There are numerous evidences that EBV miRNAs impact immune response, affect antigen presentation and recognition, change T- and B-cell communication, drive antibody production during infection, and have a role in cell apoptosis. Moreover, the ability of EBV to induce B-cell transformation and take part in mechanisms of oncogenesis in humans is well known. Although EBV infection is associated with development of various diseases, the role of its miRNAs is still not understood. There is abundant data describing EBV miRNAs in nasopharyngeal carcinoma and several studies that have tried to evaluate their role in gastric carcinoma and lymphoma. This review aims to summarize so far known data about the role of EBV miRNAs in altered regulation of gene expression in human cells in EBV-associated diseases.
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spelling pubmed-72816812020-06-15 miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis Židovec Lepej, Snježana Matulić, Maja Gršković, Paula Pavlica, Mirjana Radmanić, Leona Korać, Petra Pathogens Review Epstein-Barr virus (EBV) or human herpesvirus 4 (HHV-4) is a ubiquitous human oncogenic virus, and the first human virus found to express microRNAs (miRNAs). Its genome contains two regions encoding more than 40 miRNAs that regulate expression of both viral and human genes. There are numerous evidences that EBV miRNAs impact immune response, affect antigen presentation and recognition, change T- and B-cell communication, drive antibody production during infection, and have a role in cell apoptosis. Moreover, the ability of EBV to induce B-cell transformation and take part in mechanisms of oncogenesis in humans is well known. Although EBV infection is associated with development of various diseases, the role of its miRNAs is still not understood. There is abundant data describing EBV miRNAs in nasopharyngeal carcinoma and several studies that have tried to evaluate their role in gastric carcinoma and lymphoma. This review aims to summarize so far known data about the role of EBV miRNAs in altered regulation of gene expression in human cells in EBV-associated diseases. MDPI 2020-05-08 /pmc/articles/PMC7281681/ /pubmed/32397085 http://dx.doi.org/10.3390/pathogens9050353 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Židovec Lepej, Snježana
Matulić, Maja
Gršković, Paula
Pavlica, Mirjana
Radmanić, Leona
Korać, Petra
miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
title miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
title_full miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
title_fullStr miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
title_full_unstemmed miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
title_short miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis
title_sort mirnas: ebv mechanism for escaping host’s immune response and supporting tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281681/
https://www.ncbi.nlm.nih.gov/pubmed/32397085
http://dx.doi.org/10.3390/pathogens9050353
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