Cargando…

Adaptor CAR Platforms—Next Generation of T Cell-Based Cancer Immunotherapy

The success of conventional chimeric antigen receptor (CAR) therapy in the treatment of refractory hematologic malignancies has triggered the development of novel exciting experimental CAR technologies. Among them, adaptor CAR platforms have received much attention. They combine the flexibility and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arndt, Claudia, Fasslrinner, Frederick, Loureiro, Liliana R., Koristka, Stefanie, Feldmann, Anja, Bachmann, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281723/ https://www.ncbi.nlm.nih.gov/pubmed/32455621 http://dx.doi.org/10.3390/cancers12051302

Ejemplares similares

Targeting CD10 on B-Cell Leukemia Using the Universal CAR T-Cell Platform (UniCAR)
por: Mitwasi, Nicola, et al.
Publicado: (2022)

Targeting Acute Myeloid Leukemia Using the RevCAR Platform: A Programmable, Switchable and Combinatorial Strategy
por: Kittel-Boselli, Enrico, et al.
Publicado: (2021)

Conventional CARs versus modular CARs
por: Feldmann, Anja, et al.
Publicado: (2019)

UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells
por: Arndt, Claudia, et al.
Publicado: (2020)

Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab(®)
por: Jureczek, Justyna, et al.
Publicado: (2020)

Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
por: Loureiro, Liliana R., et al.
Publicado: (2020)

Combining Radiation- with Immunotherapy in Prostate Cancer: Influence of Radiation on T Cells
por: Lindner, Diana, et al.
Publicado: (2022)

Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells
por: Koristka, Stefanie, et al.
Publicado: (2019)

T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression
por: Kegler, Alexandra, et al.
Publicado: (2019)

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy
por: Feldmann, Anja, et al.
Publicado: (2020)

From mono- to bivalent: improving theranostic properties of target modules for redirection of UniCAR T cells against EGFR-expressing tumor cells in vitro and in vivo
por: Albert, Susann, et al.
Publicado: (2018)

An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells
por: Jureczek, Justyna, et al.
Publicado: (2019)

Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts
por: Cartellieri, M, et al.
Publicado: (2016)

Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells
por: Loureiro, L. R., et al.
Publicado: (2018)

Retargeting of T lymphocytes to PSCA- or PSMA positive prostate cancer cells using the novel modular chimeric antigen receptor platform technology “UniCAR”
por: Feldmann, Anja, et al.
Publicado: (2017)

Development of novel target modules for retargeting of UniCAR T cells to GD2 positive tumor cells
por: Mitwasi, Nicola, et al.
Publicado: (2017)

Engineering the next generation of CAR-NK immunotherapies
por: Biederstädt, Alexander, et al.
Publicado: (2021)

Characterization of a Novel Single-Chain Bispecific Antibody for Retargeting of T Cells to Tumor Cells via the TCR Co-Receptor CD8
por: Michalk, Irene, et al.
Publicado: (2014)

“UniCAR”-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells
por: Mitwasi, Nicola, et al.
Publicado: (2020)

Retargeting of UniCAR T cells with an in vivo synthesized target module directed against CD19 positive tumor cells
por: Bachmann, Dominik, et al.
Publicado: (2017)

A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR
por: Arndt, Claudia, et al.
Publicado: (2019)

Next Generation CAR T Cells for the Immunotherapy of High-Grade Glioma
por: Petersen, Christopher T., et al.
Publicado: (2019)

Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors
por: Yu, Tao, et al.
Publicado: (2022)

Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy
por: Aliperta, Roberta, et al.
Publicado: (2017)

Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy
por: Arndt, Claudia, et al.
Publicado: (2023)

Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells
por: Saleh, Haidy A., et al.
Publicado: (2023)

T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation †
por: Bachmann, Michael P., et al.
Publicado: (2021)

Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
por: Goodman, Daniel B., et al.
Publicado: (2022)

Development and Functional Characterization of a Versatile Radio-/Immunotheranostic Tool for Prostate Cancer Management
por: Arndt, Claudia, et al.
Publicado: (2022)

Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers
por: Pfeifer Serrahima, Jordi, et al.
Publicado: (2023)

CAR models: next-generation CAR modifications for enhanced T-cell function
por: Abate-Daga, Daniel, et al.
Publicado: (2016)

Validation of CD98hc as a Therapeutic Target for a Combination of Radiation and Immunotherapies in Head and Neck Squamous Cell Carcinoma
por: Köseer, Ayşe Sedef, et al.
Publicado: (2022)

TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity
por: Cartellieri, Marc, et al.
Publicado: (2013)

Armored CAR T-Cells: The Next Chapter in T-Cell Cancer Immunotherapy
por: Hawkins, Elizabeth R, et al.
Publicado: (2021)

Conditional Control of Universal CAR T Cells by Cleavable OFF-Switch Adaptors
por: Kvorjak, Michael, et al.
Publicado: (2023)

Conditional control of universal CAR T cells by cleavable OFF-switch adaptors
por: Kvorjak, Michael, et al.
Publicado: (2023)

Cytotoxic response of human regulatory T cells upon T-cell receptor-mediated activation: a matter of purity
por: Koristka, S, et al.
Publicado: (2014)

A Novel Ex Vivo Isolation and Expansion Procedure for Chimeric Antigen Receptor Engrafted Human T Cells
por: Cartellieri, Marc, et al.
Publicado: (2014)

A Small Step, a Giant Leap: Somatic Hypermutation of a Single Amino Acid Leads to Anti-La Autoreactivity
por: Bartsch, Tabea, et al.
Publicado: (2021)

Remote controlling of CAR-T cells and toxicity management: Molecular switches and next generation CARs
por: Moghanloo, Ehsan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p5vlem8l1pnj1lskg11rm1hg68