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A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)

Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-...

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Autores principales: Ortiz-Martínez, Sonia, Ramos-Rincón, José-Manuel, Vásquez-Chasnamote, María-Esteyner, Alarcón-Baldeón, Jhonatan J., Parraguez-de-la-Cruz, Jorge, Gamboa-Paredes, Olga-Nohelia, Schillyk-Guerra, Patricia, Espinoza-Venegas, Luis-Alfredo, Pinedo-Cancino, Viviana-Vanessa, Perez-Tanoira, Ramón, Górgolas-Hernández-Mora, Miguel, Casapía-Morales, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281748/
https://www.ncbi.nlm.nih.gov/pubmed/32375325
http://dx.doi.org/10.3390/pathogens9050348
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author Ortiz-Martínez, Sonia
Ramos-Rincón, José-Manuel
Vásquez-Chasnamote, María-Esteyner
Alarcón-Baldeón, Jhonatan J.
Parraguez-de-la-Cruz, Jorge
Gamboa-Paredes, Olga-Nohelia
Schillyk-Guerra, Patricia
Espinoza-Venegas, Luis-Alfredo
Pinedo-Cancino, Viviana-Vanessa
Perez-Tanoira, Ramón
Górgolas-Hernández-Mora, Miguel
Casapía-Morales, Martin
author_facet Ortiz-Martínez, Sonia
Ramos-Rincón, José-Manuel
Vásquez-Chasnamote, María-Esteyner
Alarcón-Baldeón, Jhonatan J.
Parraguez-de-la-Cruz, Jorge
Gamboa-Paredes, Olga-Nohelia
Schillyk-Guerra, Patricia
Espinoza-Venegas, Luis-Alfredo
Pinedo-Cancino, Viviana-Vanessa
Perez-Tanoira, Ramón
Górgolas-Hernández-Mora, Miguel
Casapía-Morales, Martin
author_sort Ortiz-Martínez, Sonia
collection PubMed
description Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection.
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spelling pubmed-72817482020-06-15 A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin) Ortiz-Martínez, Sonia Ramos-Rincón, José-Manuel Vásquez-Chasnamote, María-Esteyner Alarcón-Baldeón, Jhonatan J. Parraguez-de-la-Cruz, Jorge Gamboa-Paredes, Olga-Nohelia Schillyk-Guerra, Patricia Espinoza-Venegas, Luis-Alfredo Pinedo-Cancino, Viviana-Vanessa Perez-Tanoira, Ramón Górgolas-Hernández-Mora, Miguel Casapía-Morales, Martin Pathogens Article Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection. MDPI 2020-05-04 /pmc/articles/PMC7281748/ /pubmed/32375325 http://dx.doi.org/10.3390/pathogens9050348 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ortiz-Martínez, Sonia
Ramos-Rincón, José-Manuel
Vásquez-Chasnamote, María-Esteyner
Alarcón-Baldeón, Jhonatan J.
Parraguez-de-la-Cruz, Jorge
Gamboa-Paredes, Olga-Nohelia
Schillyk-Guerra, Patricia
Espinoza-Venegas, Luis-Alfredo
Pinedo-Cancino, Viviana-Vanessa
Perez-Tanoira, Ramón
Górgolas-Hernández-Mora, Miguel
Casapía-Morales, Martin
A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
title A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
title_full A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
title_fullStr A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
title_full_unstemmed A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
title_short A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
title_sort cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian amazon basin)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281748/
https://www.ncbi.nlm.nih.gov/pubmed/32375325
http://dx.doi.org/10.3390/pathogens9050348
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