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The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies

Hematopoietic stem cells (HSCs) are responsible for the production of blood cells throughout the human lifespan. Single HSCs can give rise to at least eight distinct blood-cell lineages. Together, hematopoiesis, erythropoiesis, and angiogenesis coordinate several biological processes, i.e., cellular...

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Autores principales: Sarodaya, Neha, Karapurkar, Janardhan, Kim, Kye-Seong, Hong, Seok-Ho, Ramakrishna, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281754/
https://www.ncbi.nlm.nih.gov/pubmed/32354135
http://dx.doi.org/10.3390/cancers12051103
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author Sarodaya, Neha
Karapurkar, Janardhan
Kim, Kye-Seong
Hong, Seok-Ho
Ramakrishna, Suresh
author_facet Sarodaya, Neha
Karapurkar, Janardhan
Kim, Kye-Seong
Hong, Seok-Ho
Ramakrishna, Suresh
author_sort Sarodaya, Neha
collection PubMed
description Hematopoietic stem cells (HSCs) are responsible for the production of blood cells throughout the human lifespan. Single HSCs can give rise to at least eight distinct blood-cell lineages. Together, hematopoiesis, erythropoiesis, and angiogenesis coordinate several biological processes, i.e., cellular interactions during development and proliferation, guided migration, lineage programming, and reprogramming by transcription factors. Any dysregulation of these processes can result in hematological disorders and/or malignancies. Several studies of the molecular mechanisms governing HSC maintenance have demonstrated that protein regulation by the ubiquitin proteasomal pathway is crucial for normal HSC function. Recent studies have shown that reversal of ubiquitination by deubiquitinating enzymes (DUBs) plays an equally important role in hematopoiesis; however, information regarding the biological function of DUBs is limited. In this review, we focus on recent discoveries about the physiological roles of DUBs in hematopoiesis, erythropoiesis, and angiogenesis and discuss the DUBs associated with common hematological disorders and malignancies, which are potential therapeutic drug targets.
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spelling pubmed-72817542020-06-15 The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies Sarodaya, Neha Karapurkar, Janardhan Kim, Kye-Seong Hong, Seok-Ho Ramakrishna, Suresh Cancers (Basel) Review Hematopoietic stem cells (HSCs) are responsible for the production of blood cells throughout the human lifespan. Single HSCs can give rise to at least eight distinct blood-cell lineages. Together, hematopoiesis, erythropoiesis, and angiogenesis coordinate several biological processes, i.e., cellular interactions during development and proliferation, guided migration, lineage programming, and reprogramming by transcription factors. Any dysregulation of these processes can result in hematological disorders and/or malignancies. Several studies of the molecular mechanisms governing HSC maintenance have demonstrated that protein regulation by the ubiquitin proteasomal pathway is crucial for normal HSC function. Recent studies have shown that reversal of ubiquitination by deubiquitinating enzymes (DUBs) plays an equally important role in hematopoiesis; however, information regarding the biological function of DUBs is limited. In this review, we focus on recent discoveries about the physiological roles of DUBs in hematopoiesis, erythropoiesis, and angiogenesis and discuss the DUBs associated with common hematological disorders and malignancies, which are potential therapeutic drug targets. MDPI 2020-04-28 /pmc/articles/PMC7281754/ /pubmed/32354135 http://dx.doi.org/10.3390/cancers12051103 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sarodaya, Neha
Karapurkar, Janardhan
Kim, Kye-Seong
Hong, Seok-Ho
Ramakrishna, Suresh
The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
title The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
title_full The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
title_fullStr The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
title_full_unstemmed The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
title_short The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
title_sort role of deubiquitinating enzymes in hematopoiesis and hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281754/
https://www.ncbi.nlm.nih.gov/pubmed/32354135
http://dx.doi.org/10.3390/cancers12051103
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